Identification of pyruvate kinase as an antigen associated with Tourette syndrome

Janice W. Kansy, Liliya Katsovich, Kevin S. McIver, Jennifer Pick, John B. Zabriskie, Paul J. Lombroso, James F. Leckman, James A. Bibb

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Immune responses to β-hemolytic streptococcal infections are hypothesized to trigger tic disorders and early-onset obsessive-compulsive disorder (OCD) in some pediatric populations. Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syndrome and associated disorders. Antibodies to PK reacted strongly with surface antigens of infectious strains of streptococcus, and antibodies to streptococcal M proteins reacted with PK. Moreover, immunoreactivity to PK in patients with exacerbated symptoms who had recently acquired a streptococcal infection was 7-fold higher compared to patients with exacerbated symptoms and no evidence of a streptococcal infection. These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders.

Original languageEnglish (US)
Pages (from-to)165-176
Number of pages12
JournalJournal of Neuroimmunology
Volume181
Issue number1-2
DOIs
StatePublished - Dec 1 2006

Keywords

  • Autoimmunity
  • Group A β-hemolytic streptococci
  • Obsessive-compulsive disorder
  • PANDAS
  • Pyruvate kinase
  • Tourette syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Kansy, J. W., Katsovich, L., McIver, K. S., Pick, J., Zabriskie, J. B., Lombroso, P. J., Leckman, J. F., & Bibb, J. A. (2006). Identification of pyruvate kinase as an antigen associated with Tourette syndrome. Journal of Neuroimmunology, 181(1-2), 165-176. https://doi.org/10.1016/j.jneuroim.2006.08.007