Identification of scavenger receptor B1 as the airway microfold cell receptor for mycobacterium tuberculosis

Haaris S. Khan, Vidhya R. Nair, Cody R. Ruhl, Samuel Alvarez-Arguedas, Jorge L.Galvan Rendiz, Luis H. Franco, Linzhang Huang, Philip W. Shaul, Jiwoong Kim, Yang Xie, Ron B. Mitchell, Michael U. Shiloh

Research output: Contribution to journalArticle

Abstract

Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.

Original languageEnglish (US)
Article numbere52551
JournaleLife
Volume9
DOIs
StatePublished - Mar 2020

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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