Identification of the expressed sequence tags associated with childhood acute lymphoblastic leukemia at chromosome 6q16.3

Rui Kang, Li Zhi Cao, Min Xie, Ying Chen

Research output: Contribution to journalArticle

Abstract

Objective: To identify the expressed sequence tags (EST) associated with childhood acute lymphoblastic leukemia (ALL) at chromosome 6q16.3, so as to clone candidate genes at the locus. Methods: The expression of EST at 6q16.3 in lymphocytes was detected using EST homology analysis in bioinformatics along with reverse transcription-polymerase chain reaction in 10 children with ALL and 5 healthy children. Results: The EST AA403058 expression decreased in seven of ten ALL children compared with that in healthy children (P < 0.001). Conclusions: The EST AA403058 expression is down-regulated in childhood ALL, suggesting it may be involved in the development of childhood ALL. This study provided important information toward cloning childhood ALL associated genes.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalChinese Journal of Contemporary Pediatrics
Volume7
Issue number2
StatePublished - Apr 1 2005

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Keywords

  • 6q16.3
  • Expressed sequence tags
  • Gene expression
  • Lymphoblastic leukemia, acute, childhood

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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