TY - JOUR
T1 - Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
AU - Matsumura, Yutaka
AU - Aizawa, Hiroki
AU - Shiraki-Iida, Takako
AU - Nagai, Ryozo
AU - Kuro-O, Makoto
AU - Nabeshima, Yo Ichi
PY - 1998/1/26
Y1 - 1998/1/26
N2 - Inactivation of the klotho (kl) gene in mice results in multiple disorders that resemble human aging. The mouse kl gene encodes a novel single-pass membrane protein with homology to β-glucosidases. In this study, we have isolated a human homologue of the kl gene and determined its gene structure. The human kl gene is composed of 5 exons and ranges over 50 kb on chromosome 13q12. We have further identified two transcripts that encode a membrane or secreted protein. These transcripts arise from a single kl gene through alternative RNA splicing. Expression of the putative secreted form predominates over that of the membrane form. The present study provides fundamental information necessary for further analyses of the human kl gene and its functions.
AB - Inactivation of the klotho (kl) gene in mice results in multiple disorders that resemble human aging. The mouse kl gene encodes a novel single-pass membrane protein with homology to β-glucosidases. In this study, we have isolated a human homologue of the kl gene and determined its gene structure. The human kl gene is composed of 5 exons and ranges over 50 kb on chromosome 13q12. We have further identified two transcripts that encode a membrane or secreted protein. These transcripts arise from a single kl gene through alternative RNA splicing. Expression of the putative secreted form predominates over that of the membrane form. The present study provides fundamental information necessary for further analyses of the human kl gene and its functions.
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U2 - 10.1006/bbrc.1997.8019
DO - 10.1006/bbrc.1997.8019
M3 - Article
C2 - 9464267
AN - SCOPUS:0032567647
SN - 0006-291X
VL - 242
SP - 626
EP - 630
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -