Identifying a missing lineage driver in a subset of lung neuroendocrine tumors

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tumor heterogeneity of a primary histologic cancer type has major implications for cancer research and therapeutics. An important and understudied aspect of this heterogeneity is the role of transcription factors that serve as “lineage oncogenes” in a tumor type. A demonstration that different subgroups have distinct dependencies on lineage-specific transcription factors is highlighted in a relatively homogenous cancer type: the pulmonary neuroendocrine cancer small cell lung carcinoma (SCLC). Identification of these factors is providing new insights into the origin of the heterogeneity and subtype-specific vulnerabilities in SCLC and provides a template for studying heterogeneity in other cancer types.

Original languageEnglish (US)
Pages (from-to)865-867
Number of pages3
JournalGenes and Development
Volume32
Issue number13-14
DOIs
StatePublished - Jul 1 2018

Fingerprint

Neuroendocrine Tumors
Lung
Neoplasms
Small Cell Lung Carcinoma
Transcription Factors
Therapeutic Human Experimentation
Oncogenes
Lung Neoplasms

Keywords

  • Enhancer
  • Master regulator
  • POU2F3
  • Small cell lung cancer
  • Tuft cell

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Identifying a missing lineage driver in a subset of lung neuroendocrine tumors. / Pozo, Karine; Minna, John D.; Johnson, Jane E.

In: Genes and Development, Vol. 32, No. 13-14, 01.07.2018, p. 865-867.

Research output: Contribution to journalArticle

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