Identifying the probable timing and setting of respiratory virus infections

Justin Lessler, Ron Brookmeyer, Nicholas G. Reich, Kenrad E. Nelson, Derek A T Cummings, Trish M. Perl

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective. Show how detailed incubation period estimates can be used to identify and investigate potential healthcare-associated infections and dangerous diseases. methods. We used the incubation period of 9 respiratory viruses to derive decision rules for distinguishing between community- and hospital-acquired infection. We developed a method, implemented in a simple spreadsheet, that can be used to investigate the exposure history of an individual patient and more specifically to identify the probable time and location of infection. Illustrative examples are used to explain and evaluate this technique. results. If the risks of hospital and community infection are equal, 95% of patients who develop symptoms of adenovirus infection within 5 days of hospital admission will have been infected in the community, as will 95% of patients who develop symptoms within 3 days for human-coronavirus infection, 2.5 days for severe acute respiratory syndrome, 1 day for influenza A, 0.5 day for influenza B, 12 days for measles, 2 days for parainfluenza, 4 days for respiratory syncytial virus infection, and 1.5 days for rhinovirus infection. Sources of infection suggested by analysis of the symptom onset times of individual patients are consistent with those from detailed investigations. conclusions. This work shows how a detailed understanding of the incubation period can be an effective tool for identifying the source of infection, ultimately ensuring patient safety.

Original languageEnglish (US)
Pages (from-to)809-815
Number of pages7
JournalInfection Control and Hospital Epidemiology
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2010

Fingerprint

Virus Diseases
Respiratory Tract Infections
Cross Infection
Infection
Human Influenza
Coronavirus Infections
Community-Acquired Infections
Adenoviridae Infections
Paramyxoviridae Infections
Respiratory Syncytial Virus Infections
Rhinovirus
Severe Acute Respiratory Syndrome
Community Hospital
Measles
Patient Safety
Viruses

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases
  • Medicine(all)

Cite this

Identifying the probable timing and setting of respiratory virus infections. / Lessler, Justin; Brookmeyer, Ron; Reich, Nicholas G.; Nelson, Kenrad E.; Cummings, Derek A T; Perl, Trish M.

In: Infection Control and Hospital Epidemiology, Vol. 31, No. 8, 01.08.2010, p. 809-815.

Research output: Contribution to journalArticle

Lessler, Justin ; Brookmeyer, Ron ; Reich, Nicholas G. ; Nelson, Kenrad E. ; Cummings, Derek A T ; Perl, Trish M. / Identifying the probable timing and setting of respiratory virus infections. In: Infection Control and Hospital Epidemiology. 2010 ; Vol. 31, No. 8. pp. 809-815.
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