Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III

Theodora S. Ross, Jonathan F. Tait, Philip W. Majerus

Research output: Contribution to journalArticle

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Abstract

The amino acid sequences of three fragments of cyanogen bromide - digested human placental inositol 1,2-cyclic phosphate 2-phosphohydrolase, an enzyme of the phosphatidylinositol signaling pathway, are identical to sequences within lipocortin III, a member of a family of homologous calcium- and phospholipid-binding proteins that do not have defined physiological functions. Lipocortin III has also been previously identified as placental anticoagulant protein III (PAP III) and calcimedin 35α. Antibodies to PAP m detected PAP III and inositol 1,2-cyclic phosphate 2-phosphohydrolase with identical reactivity on immunoblotting. In addition, inositol 1,2-cyclic phosphate 2-phosphohydrolase was stimulated by the same acidic phospholipids that bind lipocortins.

Original languageEnglish (US)
Pages (from-to)605-607
Number of pages3
JournalScience
Volume248
Issue number4955
DOIs
StatePublished - Jan 1 1990

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