Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III

Theodora S. Ross, Jonathan F. Tait, Philip W. Majerus

Research output: Contribution to journalArticle

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Abstract

The amino acid sequences of three fragments of cyanogen bromide-digested human placental inositol 1,2-cyclic phosphate 2-phosphohydrolase, an enzyme of the phosphatidylinositol signaling pathway, are identical to sequences within lipocortin III, a member of a family of homologous calcium- and phospholipid-binding proteins that do not have defined physiological functions. Lipocortin III has also been previously identified as placental anticoagulant protein III (PAP III) and calcimedin 35α. Antibodies to PAP III detected PAP III and inositol 1,2-cyclic phosphate 2-phosphohydrolase with identical reactivity on immunoblotting. In addition, inositol 1,2-cyclic phosphate 2-phosphohydrolase was stimulated by the same acidic phospholipids that bind lipocortins.

Original languageEnglish (US)
Pages (from-to)605-607
Number of pages3
JournalScience
Volume248
Issue number4955
StatePublished - May 4 1990

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Glycerophosphoinositol Inositolphosphodiesterase
Annexin A3
Annexins
Phospholipids
Cyanogen Bromide
Calcium-Binding Proteins
Phosphatidylinositols
Immunoblotting
Amino Acid Sequence
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. / Ross, Theodora S.; Tait, Jonathan F.; Majerus, Philip W.

In: Science, Vol. 248, No. 4955, 04.05.1990, p. 605-607.

Research output: Contribution to journalArticle

Ross, TS, Tait, JF & Majerus, PW 1990, 'Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III', Science, vol. 248, no. 4955, pp. 605-607.
Ross, Theodora S. ; Tait, Jonathan F. ; Majerus, Philip W. / Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. In: Science. 1990 ; Vol. 248, No. 4955. pp. 605-607.
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