Abstract
The amino acid sequences of three fragments of cyanogen bromide - digested human placental inositol 1,2-cyclic phosphate 2-phosphohydrolase, an enzyme of the phosphatidylinositol signaling pathway, are identical to sequences within lipocortin III, a member of a family of homologous calcium- and phospholipid-binding proteins that do not have defined physiological functions. Lipocortin III has also been previously identified as placental anticoagulant protein III (PAP III) and calcimedin 35α. Antibodies to PAP m detected PAP III and inositol 1,2-cyclic phosphate 2-phosphohydrolase with identical reactivity on immunoblotting. In addition, inositol 1,2-cyclic phosphate 2-phosphohydrolase was stimulated by the same acidic phospholipids that bind lipocortins.
Original language | English (US) |
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Pages (from-to) | 605-607 |
Number of pages | 3 |
Journal | Science |
Volume | 248 |
Issue number | 4955 |
DOIs | |
State | Published - 1990 |
ASJC Scopus subject areas
- General