Idiopathic transverse myelitis and neuromyelitis optica: Clinical profiles, pathophysiology and therapeutic choices

Amer Awad, Olaf Stüve

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Transverse myelitis is a focal inflammatory disorder of the spinal cord which may arise due to different etiologies. Transverse myelitis may be idiopathic or related/secondary to other diseases including infections, connective tissue disorders and other autoimmune diseases. It may be also associated with optic neuritis (neuromyelitis optica), which may precede transverse myelitis. In this manuscript we review the pathophysiology of different types of transverse myelitis and neuromyelitis optica and discuss diagnostic criteria for idiopathic transverse myelitis and risk of development of multiple sclerosis after an episode of transverse myelitis. We also discuss treatment options including corticosteroids, immunosuppressives and monoclonal antibodies, plasma exchange and intravenous immunoglobulins.

Original languageEnglish (US)
Pages (from-to)417-428
Number of pages12
JournalCurrent Neuropharmacology
Volume9
Issue number3
DOIs
StatePublished - Sep 1 2011

Keywords

  • Epidemiology
  • Neuromyelitis optica
  • Pathogenesis
  • Pathology
  • References
  • Transverse myelitis
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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