Abstract
Immune non-responders (INRs) are people with HIV infection who fail to restore their CD4 T-cell counts in spite of prolonged virologic suppression, a condition associated with higher rates of all-cause mortality. The mechanisms of immune non-response are not entirely clear. We used existing clinical and genetic data from AIDS Clinical Trials Group clinical trials to ask whether an IFNL4 single-nucleotide polymorphism, shown to be associated with outcomes for other infectious diseases, correlated with immune non-response for HIV. Analysis of data from 426 participants with clearly defined CD4 T-cell recovery phenotypes, including 88 INRs with CD4 < 200 cells/mm3 after 2 years of suppressive antiretroviral therapy, did not identify an association of IFNL4 genotype with immune non-response. Thus, the IFNL4 genotype is unlikely to influence immunologic recovery.
Original language | English (US) |
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Pages (from-to) | 184-188 |
Number of pages | 5 |
Journal | AIDS research and human retroviruses |
Volume | 37 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2021 |
Externally published | Yes |
Keywords
- CD4 T-cell recovery
- HIV
- IFNL4 genotype
- immune non-response
ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases