IFNL4 Genotype Does Not Associate with CD4 T-Cell Recovery in People Living with Human Immunodeficiency Virus

Eric G. Meissner, Dongjun Chung, Betty Tsao, David W. Haas, Netanya S. Utay

Research output: Contribution to journalArticlepeer-review

Abstract

Immune non-responders (INRs) are people with HIV infection who fail to restore their CD4 T-cell counts in spite of prolonged virologic suppression, a condition associated with higher rates of all-cause mortality. The mechanisms of immune non-response are not entirely clear. We used existing clinical and genetic data from AIDS Clinical Trials Group clinical trials to ask whether an IFNL4 single-nucleotide polymorphism, shown to be associated with outcomes for other infectious diseases, correlated with immune non-response for HIV. Analysis of data from 426 participants with clearly defined CD4 T-cell recovery phenotypes, including 88 INRs with CD4 < 200 cells/mm3 after 2 years of suppressive antiretroviral therapy, did not identify an association of IFNL4 genotype with immune non-response. Thus, the IFNL4 genotype is unlikely to influence immunologic recovery.

Original languageEnglish (US)
Pages (from-to)184-188
Number of pages5
JournalAIDS research and human retroviruses
Volume37
Issue number3
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • CD4 T-cell recovery
  • HIV
  • IFNL4 genotype
  • immune non-response

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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