IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes

Jenny Hsieh, James B. Aimone, Brian K. Kaspar, Tomoko Kuwabara, Kinichi Nakashima, Fred H. Gage

Research output: Contribution to journalArticle

251 Scopus citations

Abstract

Adult multipotent neural progenitor cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural progenitor cells. Here, we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of bone morphogenetic protein signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalJournal of Cell Biology
Volume164
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • BMP
  • Glia
  • Hippocampus
  • Insulin
  • Neural stem cell

ASJC Scopus subject areas

  • Cell Biology

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