IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Adrian Baican, Yoshiaki Hirako, Zelmira Lazarova, Kim B. Yancey, Detlef Zillikens, Cassian Sitaru

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume53
Issue number3
DOIs
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease'. Together they form a unique fingerprint.

  • Cite this