Abstract
Patient non-compliance and drop-out can bias analyses of clinical trial data. I describe a parametric model for treatment cross-over and drop-out and demonstrate how the concept of ignorability, originally defined for incomplete-data problems, can elucidate sources of bias in clinical trials. I discuss some implications of the theory and present simulation examples that illustrate the potential effects of non-ignorable cross-over and drop-out on bias and power.
Original language | English (US) |
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Pages (from-to) | 2421-2434 |
Number of pages | 14 |
Journal | Statistics in Medicine |
Volume | 18 |
Issue number | 17-18 |
DOIs | |
State | Published - Sep 30 1999 |
ASJC Scopus subject areas
- Epidemiology
- Statistics and Probability