IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

Yoichiro Ohne, Jonathan S. Silver, Lu Ann Thompson-Snipes, Magalie A. Collet, Jean Philippe Blanck, Brandi L. Cantarel, Alan M. Copenhaver, Alison A. Humbles, Yong Jun Liu

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Group 2 innate lymphoid cells (ILC2 cells) are important for type 2 immune responses and are activated by the epithelial cytokines interleukin 33 (IL-33), IL-25 and thymic stromal lymphopoietin (TSLP). Here we demonstrated that IL-1β was a critical activator of ILC2 cells, inducing proliferation and cytokine production and regulating the expression of epithelial cytokine receptors. IL-1β also governed ILC2 plasticity by inducing low expression of the transcription factor T-bet and the cytokine receptor chain IL-12Rβ2, which enabled the conversion of these cells into an ILC1 phenotype in response to IL-12. This transition was marked by an atypical chromatin landscape characterized by the simultaneous transcriptional accessibility of the locus encoding interferon-γ (IFN-γ) and the loci encoding IL-5 and IL-13. Finally, IL-1β potentiated ILC2 activation and plasticity in vivo, and IL-12 acted as the switch that determined an ILC2-versus-ILC1 response. Thus, we have identified a previously unknown role for IL-1β in facilitating ILC2 maturation and plasticity.

Original languageEnglish (US)
Pages (from-to)646-655
Number of pages10
JournalNature Immunology
Volume17
Issue number6
DOIs
StatePublished - May 19 2016

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Interleukin-1
Lymphocytes
Cytokine Receptors
Interleukin-12
Cytokines
Interleukin-13
Interleukin-5
Interferons
Chromatin
Cell Proliferation
Phenotype
Cell Plasticity

ASJC Scopus subject areas

  • Immunology

Cite this

Ohne, Y., Silver, J. S., Thompson-Snipes, L. A., Collet, M. A., Blanck, J. P., Cantarel, B. L., ... Liu, Y. J. (2016). IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. Nature Immunology, 17(6), 646-655. https://doi.org/10.1038/ni.3447

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. / Ohne, Yoichiro; Silver, Jonathan S.; Thompson-Snipes, Lu Ann; Collet, Magalie A.; Blanck, Jean Philippe; Cantarel, Brandi L.; Copenhaver, Alan M.; Humbles, Alison A.; Liu, Yong Jun.

In: Nature Immunology, Vol. 17, No. 6, 19.05.2016, p. 646-655.

Research output: Contribution to journalArticle

Ohne, Y, Silver, JS, Thompson-Snipes, LA, Collet, MA, Blanck, JP, Cantarel, BL, Copenhaver, AM, Humbles, AA & Liu, YJ 2016, 'IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity', Nature Immunology, vol. 17, no. 6, pp. 646-655. https://doi.org/10.1038/ni.3447
Ohne Y, Silver JS, Thompson-Snipes LA, Collet MA, Blanck JP, Cantarel BL et al. IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. Nature Immunology. 2016 May 19;17(6):646-655. https://doi.org/10.1038/ni.3447
Ohne, Yoichiro ; Silver, Jonathan S. ; Thompson-Snipes, Lu Ann ; Collet, Magalie A. ; Blanck, Jean Philippe ; Cantarel, Brandi L. ; Copenhaver, Alan M. ; Humbles, Alison A. ; Liu, Yong Jun. / IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. In: Nature Immunology. 2016 ; Vol. 17, No. 6. pp. 646-655.
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