IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

Yoichiro Ohne, Jonathan S. Silver, Lu Ann Thompson-Snipes, Magalie A. Collet, Jean Philippe Blanck, Brandi L. Cantarel, Alan M. Copenhaver, Alison A. Humbles, Yong Jun Liu

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

Group 2 innate lymphoid cells (ILC2 cells) are important for type 2 immune responses and are activated by the epithelial cytokines interleukin 33 (IL-33), IL-25 and thymic stromal lymphopoietin (TSLP). Here we demonstrated that IL-1β was a critical activator of ILC2 cells, inducing proliferation and cytokine production and regulating the expression of epithelial cytokine receptors. IL-1β also governed ILC2 plasticity by inducing low expression of the transcription factor T-bet and the cytokine receptor chain IL-12Rβ2, which enabled the conversion of these cells into an ILC1 phenotype in response to IL-12. This transition was marked by an atypical chromatin landscape characterized by the simultaneous transcriptional accessibility of the locus encoding interferon-γ (IFN-γ) and the loci encoding IL-5 and IL-13. Finally, IL-1β potentiated ILC2 activation and plasticity in vivo, and IL-12 acted as the switch that determined an ILC2-versus-ILC1 response. Thus, we have identified a previously unknown role for IL-1β in facilitating ILC2 maturation and plasticity.

Original languageEnglish (US)
Pages (from-to)646-655
Number of pages10
JournalNature Immunology
Volume17
Issue number6
DOIs
StatePublished - May 19 2016

ASJC Scopus subject areas

  • Immunology

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    Ohne, Y., Silver, J. S., Thompson-Snipes, L. A., Collet, M. A., Blanck, J. P., Cantarel, B. L., Copenhaver, A. M., Humbles, A. A., & Liu, Y. J. (2016). IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity. Nature Immunology, 17(6), 646-655. https://doi.org/10.1038/ni.3447