IL-17 promotes immune privilege of corneal allografts

Khrishen Cunnusamy, Peter W. Chen, Jerry Y. Niederkorn

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Corneal allograft rejection has been described as a Th1-mediated process involving IFN-γ production. However, it has been reported that corneal allograft rejection soars in IFN-γ-/- mice or mice treated with anti-IFN-γ mAb. Th17 is a recently described IL-17A-producing Th cell population that has been linked to renal and cardiac graft rejection, which was originally thought to be Th1-mediated. We tested the hypothesis that Th17 cells mediate corneal allograft rejection in an IL-17A-dependent fashion and unexpectedly found that depletion of IL-17A increased the incidence of rejection to 90%. We demonstrate that the exacerbated rejection following depletion of IL-17A did not result from a loss of cross-regulation of Th1 cells or exaggerated delayed-type hypersensitivity responses. Instead, inhibition of the Th1 or Th17 cell lineages promoted the emergence of a Th2 cell subset that independently mediated allograft rejection. These findings demonstrate that IL-17A is not required for corneal allograft rejection and may instead contribute to the immune privilege of corneal allografts.

Original languageEnglish (US)
Pages (from-to)4651-4658
Number of pages8
JournalJournal of Immunology
Volume185
Issue number8
DOIs
StatePublished - Oct 15 2010

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Interleukin-17
Allografts
Th17 Cells
Th1 Cells
Th2 Cells
Delayed Hypersensitivity
Graft Rejection
Cell Lineage
Kidney
Incidence
Population

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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IL-17 promotes immune privilege of corneal allografts. / Cunnusamy, Khrishen; Chen, Peter W.; Niederkorn, Jerry Y.

In: Journal of Immunology, Vol. 185, No. 8, 15.10.2010, p. 4651-4658.

Research output: Contribution to journalArticle

Cunnusamy, Khrishen ; Chen, Peter W. ; Niederkorn, Jerry Y. / IL-17 promotes immune privilege of corneal allografts. In: Journal of Immunology. 2010 ; Vol. 185, No. 8. pp. 4651-4658.
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