IL-17 promotes immune privilege of corneal allografts

Khrishen Cunnusamy, Peter W. Chen, Jerry Y. Niederkorn

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Corneal allograft rejection has been described as a Th1-mediated process involving IFN-γ production. However, it has been reported that corneal allograft rejection soars in IFN-γ-/- mice or mice treated with anti-IFN-γ mAb. Th17 is a recently described IL-17A-producing Th cell population that has been linked to renal and cardiac graft rejection, which was originally thought to be Th1-mediated. We tested the hypothesis that Th17 cells mediate corneal allograft rejection in an IL-17A-dependent fashion and unexpectedly found that depletion of IL-17A increased the incidence of rejection to 90%. We demonstrate that the exacerbated rejection following depletion of IL-17A did not result from a loss of cross-regulation of Th1 cells or exaggerated delayed-type hypersensitivity responses. Instead, inhibition of the Th1 or Th17 cell lineages promoted the emergence of a Th2 cell subset that independently mediated allograft rejection. These findings demonstrate that IL-17A is not required for corneal allograft rejection and may instead contribute to the immune privilege of corneal allografts.

Original languageEnglish (US)
Pages (from-to)4651-4658
Number of pages8
JournalJournal of Immunology
Volume185
Issue number8
DOIs
StatePublished - Oct 15 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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