IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

Nathalie Heuzé-Vourc'h, Ming Liu, Harnisha Dalwadi, Felicita E. Baratelli, Li Zhu, Lee Goodglick, Mehis Põld, Sherven Sharma, Ruben D. Ramirez, Jerry W. Shay, John D. Minna, Robert M. Strieter, Steven M. Dubinett

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

COX-2 overexpression and subsequent PGE2 production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE2 in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE2 occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE2 and inhibits angiogenesis.

Original languageEnglish (US)
Pages (from-to)470-475
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume333
Issue number2
DOIs
StatePublished - Jul 29 2005

Keywords

  • Angiogenesis
  • Cyclooxygenase-2
  • Human bronchial epithelial cells
  • Interleukin-20
  • Lung cancer
  • NSCLC
  • Prostaglandin-E

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Heuzé-Vourc'h, N., Liu, M., Dalwadi, H., Baratelli, F. E., Zhu, L., Goodglick, L., Põld, M., Sharma, S., Ramirez, R. D., Shay, J. W., Minna, J. D., Strieter, R. M., & Dubinett, S. M. (2005). IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Biochemical and Biophysical Research Communications, 333(2), 470-475. https://doi.org/10.1016/j.bbrc.2005.05.122