IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

Nathalie Heuzé-Vourc'h; Ming Liu; Harnisha Dalwadi; Felicita E. Baratelli; Li Zhu; Lee Goodglick; Mehis Põld; Sherven Sharma; Ruben D. Ramirez; Jerry W. Shay; John D. Minna; Robert M. Strieter; Steven M. Dubinett

doi:10.1016/j.bbrc.2005.05.122

IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

Nathalie Heuzé-Vourc'h, Ming Liu, Harnisha Dalwadi, Felicita E. Baratelli, Li Zhu, Lee Goodglick, Mehis Põld, Sherven Sharma, Ruben D. Ramirez, Jerry W. Shay, John D. Minna, Robert M. Strieter, Steven M. Dubinett

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

COX-2 overexpression and subsequent PGE₂ production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE₂ in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE₂ occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE₂ and inhibits angiogenesis.

Original language	English (US)
Pages (from-to)	470-475
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	333
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2005.05.122
State	Published - Jul 29 2005

Keywords

Angiogenesis
Cyclooxygenase-2
Human bronchial epithelial cells
Interleukin-20
Lung cancer
NSCLC
Prostaglandin-E

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.05.122

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Heuzé-Vourc'h, N., Liu, M., Dalwadi, H., Baratelli, F. E., Zhu, L., Goodglick, L., Põld, M., Sharma, S., Ramirez, R. D., Shay, J. W., Minna, J. D., Strieter, R. M., & Dubinett, S. M. (2005). IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Biochemical and Biophysical Research Communications, 333(2), 470-475. https://doi.org/10.1016/j.bbrc.2005.05.122

@article{73ab29324eb34dd388de9d65a2b53724,

title = "IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression",

abstract = "COX-2 overexpression and subsequent PGE2 production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE2 in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE2 occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE2 and inhibits angiogenesis.",

keywords = "Angiogenesis, Cyclooxygenase-2, Human bronchial epithelial cells, Interleukin-20, Lung cancer, NSCLC, Prostaglandin-E",

author = "Nathalie Heuz{\'e}-Vourc'h and Ming Liu and Harnisha Dalwadi and Baratelli, {Felicita E.} and Li Zhu and Lee Goodglick and Mehis P{\~o}ld and Sherven Sharma and Ramirez, {Ruben D.} and Shay, {Jerry W.} and Minna, {John D.} and Strieter, {Robert M.} and Dubinett, {Steven M.}",

note = "Funding Information: This work was supported by the UCLA SPORE in Lung Cancer, National Institutes of Health Grants P50 CA90388 and RO1 CA85686, the American Lung Association, Merit Review Research Funds from the Department of Veterans Affairs, and the Tobacco-Related Disease Research Program of the University of California. Funding Information: Flow cytometry was performed in the UCLA Jonsson Comprehensive Cancer Center and Center for AIDS Research Flow Cytometry Core Facility that is supported by National Institutes of Health awards CA-16042 and AI-28697, by the Jonsson Cancer Center, the UCLA AIDS Institute, and the David Geffen School of Medicine at UCLA.",

year = "2005",

month = jul,

day = "29",

doi = "10.1016/j.bbrc.2005.05.122",

language = "English (US)",

volume = "333",

pages = "470--475",

journal = "Biochemical and Biophysical Research Communications",

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T1 - IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

AU - Heuzé-Vourc'h, Nathalie

AU - Liu, Ming

AU - Dalwadi, Harnisha

AU - Baratelli, Felicita E.

AU - Zhu, Li

AU - Goodglick, Lee

AU - Põld, Mehis

AU - Sharma, Sherven

AU - Ramirez, Ruben D.

AU - Shay, Jerry W.

AU - Minna, John D.

AU - Strieter, Robert M.

AU - Dubinett, Steven M.

N1 - Funding Information: This work was supported by the UCLA SPORE in Lung Cancer, National Institutes of Health Grants P50 CA90388 and RO1 CA85686, the American Lung Association, Merit Review Research Funds from the Department of Veterans Affairs, and the Tobacco-Related Disease Research Program of the University of California. Funding Information: Flow cytometry was performed in the UCLA Jonsson Comprehensive Cancer Center and Center for AIDS Research Flow Cytometry Core Facility that is supported by National Institutes of Health awards CA-16042 and AI-28697, by the Jonsson Cancer Center, the UCLA AIDS Institute, and the David Geffen School of Medicine at UCLA.

PY - 2005/7/29

Y1 - 2005/7/29

N2 - COX-2 overexpression and subsequent PGE2 production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE2 in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE2 occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE2 and inhibits angiogenesis.

AB - COX-2 overexpression and subsequent PGE2 production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE2 in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE2 occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE2 and inhibits angiogenesis.

KW - Angiogenesis

KW - Cyclooxygenase-2

KW - Human bronchial epithelial cells

KW - Interleukin-20

KW - Lung cancer

KW - NSCLC

KW - Prostaglandin-E

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SN - 0006-291X

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EP - 475

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression

Abstract

Keywords

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