IL-23 induces receptor activator of NF-κB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model

Hyeon Ju Ji, Mi La Cho, Young Mee Moon, Hye Joa Oh, Jin Sil Park, Joo Youn Jhun, So Youn Min, Young Gyu Cho, Kyung Su Park, Chong Hyeon Yoon, Jun Ki Min, Sung Hwan Park, Young Chul Sung, Ho Youn Kim

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

IL-23, a clinically novel cytokine, targets CD4+ T cells. Recent IL-1Ra-/- mouse studies have demonstrated that IL-23 indirectly stimulates the differentiation of osteoclast precursors by enhancing IL-17 release from CD4+ T cells. IL-17, in turn, stimulates osteoclastogenesis in osteoclast precursor cells. In this study, we found that IL-23 up-regulates receptor activator of NF-κB ligand expression by CD4+ T cells, and thus contributes to osteoclastogenesis. This indirect pathway is mediated by NF-κB and STAT3. We have also demonstrated that IL-23 can influence osteoclastogenesis positively under the special conditions in the IL-1-dominant milieu of IL-1Ra-/- mice. We propose that IL-23-enhanced osteoclastogenesis is mediated mainly by CD4+ T cells. The results of this study show that IL-23 is a promising therapeutic target for the treatment of arthritis-associated bone destruction.

Original languageEnglish (US)
Pages (from-to)1507-1518
Number of pages12
JournalJournal of Immunology
Volume181
Issue number2
DOIs
StatePublished - Jul 15 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Ji, H. J., Cho, M. L., Moon, Y. M., Oh, H. J., Park, J. S., Jhun, J. Y., Min, S. Y., Cho, Y. G., Park, K. S., Yoon, C. H., Min, J. K., Park, S. H., Sung, Y. C., & Kim, H. Y. (2008). IL-23 induces receptor activator of NF-κB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model. Journal of Immunology, 181(2), 1507-1518. https://doi.org/10.4049/jimmunol.181.2.1507