IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii

Julie Mirpuri, Felix Yarovinsky

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

SOCS are a family of proteins that play an important role in the negative regulation of the cytokine-JAK-STAT pathway. Socs3 deletion results in prolonged IL-6 signaling measured by STAT3 phosphorylation. A role for STAT3 and SOCS3 in the context of Toxoplasma gondii infection is of particular importance, because STAT3 appears to be a key target of T. gondii virulence factors. By utilizing LysM-cre Socs3 fl/fl mice, the Hunter laboratory recently established that macrophage-specific SOCS3 knockout mice have enhanced susceptibility to infection with T. gondii. The authors demonstrated that lack of SOCS3-mediated control of IL-6 signaling results in acute susceptibility to T. gondii due to impaired IL-12 production by inflammatory monocytes, macrophages and neutrophils. This article further explores these findings and their implications in the field of host resistance to microbial pathogens.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalFuture Microbiology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • IL-12
  • IL-6
  • SOCS
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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