IL28B: Implications for therapy

Arjmand R. Mufti; Nancy Reau

doi:10.1007/s11901-011-0099-x

IL28B: Implications for therapy

Research output: Contribution to journal › Article › peer-review

Abstract

Within the last 2 years, a number of Genome- Wide Association Studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) gene region, encoding interferon-λ3, are predictive of hepatitis C clearance in patients receiving interferon-α and ribavirin-based treatment regimens. In addition, the same SNPs are strongly linked with spontaneous clearance of hepatitis C virus in treatment-naïve patients. The causal variant responsible for these findings has not been identified. Nevertheless, the discovery of a correlation between the IL28B genotype status and treatment outcome has impacted all aspects of clinical decision making in patients with hepatitis C, and has opened up the very real possibility of individualized treatment regimens based on variations at the IL28B gene locus.

Original language	English (US)
Pages (from-to)	153-161
Number of pages	9
Journal	Current Hepatitis Reports
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s11901-011-0099-x
State	Published - Sep 2011

Keywords

Current and future therapies, Interleukin-28B
Hepatitis C Virus
IL28B Polymorphism
Interferon
Ribavirin

ASJC Scopus subject areas

Hepatology
Virology

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10.1007/s11901-011-0099-x

Cite this

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abstract = "Within the last 2 years, a number of Genome- Wide Association Studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) gene region, encoding interferon-λ3, are predictive of hepatitis C clearance in patients receiving interferon-α and ribavirin-based treatment regimens. In addition, the same SNPs are strongly linked with spontaneous clearance of hepatitis C virus in treatment-na{\"i}ve patients. The causal variant responsible for these findings has not been identified. Nevertheless, the discovery of a correlation between the IL28B genotype status and treatment outcome has impacted all aspects of clinical decision making in patients with hepatitis C, and has opened up the very real possibility of individualized treatment regimens based on variations at the IL28B gene locus.",

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IL28B: Implications for therapy

Abstract

Keywords

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