IL28B: Implications for therapy

Arjmand R. Mufti, Nancy Reau

Research output: Contribution to journalArticlepeer-review

Abstract

Within the last 2 years, a number of Genome- Wide Association Studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) gene region, encoding interferon-λ3, are predictive of hepatitis C clearance in patients receiving interferon-α and ribavirin-based treatment regimens. In addition, the same SNPs are strongly linked with spontaneous clearance of hepatitis C virus in treatment-naïve patients. The causal variant responsible for these findings has not been identified. Nevertheless, the discovery of a correlation between the IL28B genotype status and treatment outcome has impacted all aspects of clinical decision making in patients with hepatitis C, and has opened up the very real possibility of individualized treatment regimens based on variations at the IL28B gene locus.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalCurrent Hepatitis Reports
Volume10
Issue number3
DOIs
StatePublished - Sep 1 2011

Keywords

  • Current and future therapies, Interleukin-28B
  • Hepatitis C Virus
  • IL28B Polymorphism
  • Interferon
  • Ribavirin

ASJC Scopus subject areas

  • Hepatology
  • Virology

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