TY - JOUR
T1 - Illness perceptions in chronic lymphocytic leukemia
T2 - Testing Leventhal's Self-regulatory Model
AU - Westbrook, Travis D.
AU - Morrison, Eleshia J.
AU - Maddocks, Kami J.
AU - Awan, Farrukh T.
AU - Jones, Jeffrey A.
AU - Woyach, Jennifer A.
AU - Johnson, Amy J.
AU - Byrd, John C.
AU - Andersen, Barbara L.
N1 - Funding Information:
Conflict of Interest K.M. has received research funding from Pharmacyclics. J.W. has received research funding from Morphosys, Karyopharm, Abbvie, Acerta, and served as a consultant for Janssen. J.B. has received research funding from Genentech, Janssen, Acerta, and Pharmacyclics.
Funding Information:
Funding This research was supported in part by a Pelotonia Idea Award and a Pelotonia Graduate Fellowship from the Ohio State University Comprehensive Cancer Center and Solove Research Institute, the National Institutes of Health/National Cancer Institute (K05 CA098133, K12 CA133250, R35 CA197734, RO1 CA177292), Pharmacyclics, the Specialized Center of Research from the Leukemia and Lymphoma Society, and the D. Warren Brown Foundation.
Funding Information:
This research was supported in part by a Pelotonia Idea Award and a Pelotonia Graduate Fellowship from the Ohio State University Comprehensive Cancer Center and Solove Research Institute, the National Institutes of Health/National Cancer Institute (K05 CA098133, K12 CA133250, R35 CA197734, RO1 CA177292), Pharmacyclics, the Specialized Center of Research from the Leukemia and Lymphoma Society, and the D. Warren Brown Foundation.
Publisher Copyright:
© Society of Behavioral Medicine 2018.
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Background Leventhal's Self-regulatory Model proposes that somatic characteristics of a health threat (e.g., symptom severity), and prior experience with the threat (e.g., unsuccessful treatment), are determinants of illness perceptions. Chronic lymphocytic leukemia (CLL) is appropriate for test of these postulates, having three phases differing in symptom severity and prior treatment experiences: indolent disease requiring no treatment (active surveillance; AS), symptomatic disease requiring a first treatment (FT), and highly symptomatic disease in those who have relapsed and/or failed to respond to prior treatments (relapsed/refractory; RR). Purpose To test symptom severity and prior treatment experiences as determinants of illness perceptions, illness perceptions were characterized and contrasted between CLL groups. Methods Three hundred and thirty CLL patients (AS, n = 100; FT, n = 78; RR, n = 152) provided illness perception data on one occasion during a surveillance visit (AS) or prior to beginning treatment (FT, RR). Results Analysis of variance with planned comparisons revealed that consequences, identity, and concern were least favorable among RR patients, followed by FT, then AS (ps < .01). AS patients endorsed the lowest levels of coherence (ps < .01), and the most chronic illness timeline (ps < .01). FT patients endorsed the highest levels of personal and treatment control (ps < .01). Conclusions Data provide preliminary empirical support for Self-regulatory Model postulates that symptom severity and prior disease experiences influence illness perceptions. Unique knowledge needs for AS patients and elevated psychological/physical symptoms for later-stage CLL patients may warrant clinical attention.
AB - Background Leventhal's Self-regulatory Model proposes that somatic characteristics of a health threat (e.g., symptom severity), and prior experience with the threat (e.g., unsuccessful treatment), are determinants of illness perceptions. Chronic lymphocytic leukemia (CLL) is appropriate for test of these postulates, having three phases differing in symptom severity and prior treatment experiences: indolent disease requiring no treatment (active surveillance; AS), symptomatic disease requiring a first treatment (FT), and highly symptomatic disease in those who have relapsed and/or failed to respond to prior treatments (relapsed/refractory; RR). Purpose To test symptom severity and prior treatment experiences as determinants of illness perceptions, illness perceptions were characterized and contrasted between CLL groups. Methods Three hundred and thirty CLL patients (AS, n = 100; FT, n = 78; RR, n = 152) provided illness perception data on one occasion during a surveillance visit (AS) or prior to beginning treatment (FT, RR). Results Analysis of variance with planned comparisons revealed that consequences, identity, and concern were least favorable among RR patients, followed by FT, then AS (ps < .01). AS patients endorsed the lowest levels of coherence (ps < .01), and the most chronic illness timeline (ps < .01). FT patients endorsed the highest levels of personal and treatment control (ps < .01). Conclusions Data provide preliminary empirical support for Self-regulatory Model postulates that symptom severity and prior disease experiences influence illness perceptions. Unique knowledge needs for AS patients and elevated psychological/physical symptoms for later-stage CLL patients may warrant clinical attention.
KW - Active surveillance
KW - Chronic lymphocytic leukemia
KW - Illness perceptions
KW - Relapsed refractory disease
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U2 - 10.1093/abm/kay093
DO - 10.1093/abm/kay093
M3 - Article
C2 - 30590383
AN - SCOPUS:85071555796
SN - 0883-6612
VL - 53
SP - 839
EP - 848
JO - Annals of Behavioral Medicine
JF - Annals of Behavioral Medicine
IS - 9
ER -