Iloprost enhances survival of axial-pattern skin flaps in an ischemia- reperfusion model

U. Rajagopal, R. M. Friedman, J. B. Robinson, R. J. Rohrich

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no apparent side effects were noted.

Original languageEnglish (US)
Pages (from-to)884-887
Number of pages4
JournalPlastic and Reconstructive Surgery
Volume95
Issue number5
StatePublished - 1995

Fingerprint

Iloprost
Groin
Epoprostenol
Reperfusion
Ischemia
Skin

ASJC Scopus subject areas

  • Surgery

Cite this

Rajagopal, U., Friedman, R. M., Robinson, J. B., & Rohrich, R. J. (1995). Iloprost enhances survival of axial-pattern skin flaps in an ischemia- reperfusion model. Plastic and Reconstructive Surgery, 95(5), 884-887.

Iloprost enhances survival of axial-pattern skin flaps in an ischemia- reperfusion model. / Rajagopal, U.; Friedman, R. M.; Robinson, J. B.; Rohrich, R. J.

In: Plastic and Reconstructive Surgery, Vol. 95, No. 5, 1995, p. 884-887.

Research output: Contribution to journalArticle

Rajagopal, U, Friedman, RM, Robinson, JB & Rohrich, RJ 1995, 'Iloprost enhances survival of axial-pattern skin flaps in an ischemia- reperfusion model', Plastic and Reconstructive Surgery, vol. 95, no. 5, pp. 884-887.
Rajagopal, U. ; Friedman, R. M. ; Robinson, J. B. ; Rohrich, R. J. / Iloprost enhances survival of axial-pattern skin flaps in an ischemia- reperfusion model. In: Plastic and Reconstructive Surgery. 1995 ; Vol. 95, No. 5. pp. 884-887.
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