Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model

U. Rajagopal, R. M. Friedman, J. B. Robinson, R. J. Rohrich

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no ap-parent side effects were noted.

Original languageEnglish (US)
Pages (from-to)884-887
Number of pages4
JournalPlastic and reconstructive surgery
Volume95
Issue number4
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Surgery

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    Rajagopal, U., Friedman, R. M., Robinson, J. B., & Rohrich, R. J. (1995). Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model. Plastic and reconstructive surgery, 95(4), 884-887.