Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no ap-parent side effects were noted.
|Original language||English (US)|
|Number of pages||4|
|Journal||Plastic and reconstructive surgery|
|State||Published - Apr 1995|
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