Image-guided stereotactic small animal irradiator

R. Pidikiti, S. Stojadinovic, K. Song, M. Speiser, S. Seliounine, D. Saha, T. D. Solberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Stereotactic body radiation therapy (SBRT) is a promising modality in the treatment of cancer. Despite success in early clinical applications and in subsequent clinical trials, there remains much to learn to understand and optimize the effects in tumors and normal tissues. In this study, we develop and characterize an image-guided small animal stereotactic body irradiator capable of delivering a highly localized radiation beam accurately to a small target. The irradiator employs a commercial X-ray device (XRAD 320, Precision X-Ray, Inc.) and a modular collimation system, consisting of a brass collimator holder and variable tungsten alloy collimators with apertures ranging from 1 to 10 mm in diameter. The unit is typically operated at 30 kVp for image guidance and at 250 kVp for therapy. To characterize the radiation beam, we measured percent depth dose (PDD), off-axis ratios (OARs), and absolute dose rate for each collimator using radiochromic film (Gafchromic EBT, International Specialty Products, Wayne, NJ). For all collimators the penumbra, defined as distance between 80% and 20% isodoses, was measured at a source-to-surface distance (SSD) of approximately 20 cm. For a 5 mm collimator, in-plane and cross-plane measurements of penumbra were 0.7 and 1.1 mm, respectively. Absolute dose rates ranged from 6.7 to 11.6 Gy/min for the 1 to 10 mm collimators. The image guidance system provided accuracy commensurate with stereotactic localization in small animals. We have demonstrated the capability of an image-guided stereotactic radiotherapy by the animal studies. Subsequent studies in a variety of pre-clinical tumor and normal tissue models suggest that use of the irradiator can significantly contribute to the understanding of new clinical therapies such as SBRT.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationSpecial Topics and Workshops
Pages55-58
Number of pages4
Edition13
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number13
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Image guided radiotherapy
  • SBRT
  • Small animal irradiation
  • kV dosimetry

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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