Image registration for interventional MRI guided procedures: Interpolation methods, similarity measurements, and applications to the prostate

Baowei Fei, Zhenghong Lee, Jeffery L. Duerk, David L. Wilson

Research output: Contribution to journalArticle

11 Scopus citations


Nuclear medicine can detect and localize tumor in the prostate not reliably seen in MR. We are investigating methods to combine the advantages of SPECT with interventional MRI (iMRI) guided radiofrequency thermal ablation of the prostate. Our approach is to first register the low-resolution functional images with a high resolution MR volume. Then, by combining the high-resolution MR image with live-time iMRI acquisitions, we can, in turn, include the functional data and high-resolution anatomic information into the iMRI system for improved tumor targeting. In this study, we investigated registration methods for combining noisy, thick iMRI image slices with high-resolution MR volumes. We compared three similarity measures, i.e., normalized mutual information, mutual information, and correlation coefficient; and three interpolation methods, i.e., re-normalized sine, tri-linear, and nearest neighbor. Registration experiments showed that transverse slice images covering the prostate work best with a registration error of ≈ 0.5 mm as compared to our volume-to-volume registration that was previously shown to be quite accurate for these image pairs.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Publication statusPublished - Dec 1 2003
Externally publishedYes


ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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