Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice

Baowei Fei, Chris Flask, Wang Hesheng, Ai Pi, David L. Wilson, Jonathan Shillingford, Noel Murcia, Thomas Weimbs, Jeffrey L. Duerk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD mice immediately prior to, and 2-week and 4-week after therapy. We developed image segmentation, registration and visualization methods for this novel imaging application. We measured the kidney volumes for each mouse to assess the efficacy of the therapy. The segmentation results show that the kidney volumes are consistent, which are 348.7 ± 19.7 mm 3 for wild-type mice and 756.3 ± 44.1 mm3 for transgenic mice, respectively. The image analysis methods provide a useful tool for this new application.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages467-469
Number of pages3
StatePublished - Dec 1 2005
Externally publishedYes
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

Keywords

  • Image segmentation
  • Magnetic resonance imaging (MRI)
  • Polycystic kidney disease
  • Registration
  • Transgenic mice
  • Visualization

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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