Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice

Baowei Fei; Chris Flask; Wang Hesheng; Ai Pi; David L. Wilson; Jonathan Shillingford; Noel Murcia; Thomas Weimbs; Jeffrey L. Duerk

Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice

Baowei Fei, Chris Flask, Wang Hesheng, Ai Pi, David L. Wilson, Jonathan Shillingford, Noel Murcia, Thomas Weimbs, Jeffrey L. Duerk

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

12 Scopus citations

Abstract

In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD mice immediately prior to, and 2-week and 4-week after therapy. We developed image segmentation, registration and visualization methods for this novel imaging application. We measured the kidney volumes for each mouse to assess the efficacy of the therapy. The segmentation results show that the kidney volumes are consistent, which are 348.7 ± 19.7 mm ³ for wild-type mice and 756.3 ± 44.1 mm³ for transgenic mice, respectively. The image analysis methods provide a useful tool for this new application.

Original language	English (US)
Title of host publication	Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages	467-469
Number of pages	3
State	Published - 2005
Externally published	Yes
Event	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China Duration: Sep 1 2005 → Sep 4 2005

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	7 VOLS
ISSN (Print)	0589-1019

Other

Other	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Country/Territory	China
City	Shanghai
Period	9/1/05 → 9/4/05

Keywords

Image segmentation
Magnetic resonance imaging (MRI)
Polycystic kidney disease
Registration
Transgenic mice
Visualization

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Fei, B., Flask, C., Hesheng, W., Pi, A., Wilson, D. L., Shillingford, J., Murcia, N., Weimbs, T., & Duerk, J. L. (2005). Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 467-469). Article 1616448 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. / Fei, Baowei; Flask, Chris; Hesheng, Wang et al.
Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 467-469 1616448 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Fei, B, Flask, C, Hesheng, W, Pi, A, Wilson, DL, Shillingford, J, Murcia, N, Weimbs, T & Duerk, JL 2005, Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1616448, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, pp. 467-469, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 9/1/05.

Fei B, Flask C, Hesheng W, Pi A, Wilson DL, Shillingford J et al. Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 467-469. 1616448. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Fei, Baowei ; Flask, Chris ; Hesheng, Wang et al. / Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. pp. 467-469 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

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abstract = "In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD mice immediately prior to, and 2-week and 4-week after therapy. We developed image segmentation, registration and visualization methods for this novel imaging application. We measured the kidney volumes for each mouse to assess the efficacy of the therapy. The segmentation results show that the kidney volumes are consistent, which are 348.7 ± 19.7 mm 3 for wild-type mice and 756.3 ± 44.1 mm3 for transgenic mice, respectively. The image analysis methods provide a useful tool for this new application.",

keywords = "Image segmentation, Magnetic resonance imaging (MRI), Polycystic kidney disease, Registration, Transgenic mice, Visualization",

author = "Baowei Fei and Chris Flask and Wang Hesheng and Ai Pi and Wilson, {David L.} and Jonathan Shillingford and Noel Murcia and Thomas Weimbs and Duerk, {Jeffrey L.}",

year = "2005",

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AU - Fei, Baowei

AU - Flask, Chris

AU - Hesheng, Wang

AU - Pi, Ai

AU - Wilson, David L.

AU - Shillingford, Jonathan

AU - Murcia, Noel

AU - Weimbs, Thomas

AU - Duerk, Jeffrey L.

PY - 2005

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N2 - In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD mice immediately prior to, and 2-week and 4-week after therapy. We developed image segmentation, registration and visualization methods for this novel imaging application. We measured the kidney volumes for each mouse to assess the efficacy of the therapy. The segmentation results show that the kidney volumes are consistent, which are 348.7 ± 19.7 mm 3 for wild-type mice and 756.3 ± 44.1 mm3 for transgenic mice, respectively. The image analysis methods provide a useful tool for this new application.

AB - In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD mice immediately prior to, and 2-week and 4-week after therapy. We developed image segmentation, registration and visualization methods for this novel imaging application. We measured the kidney volumes for each mouse to assess the efficacy of the therapy. The segmentation results show that the kidney volumes are consistent, which are 348.7 ± 19.7 mm 3 for wild-type mice and 756.3 ± 44.1 mm3 for transgenic mice, respectively. The image analysis methods provide a useful tool for this new application.

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KW - Magnetic resonance imaging (MRI)

KW - Polycystic kidney disease

KW - Registration

KW - Transgenic mice

KW - Visualization

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ER -

Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice

Abstract

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Keywords

ASJC Scopus subject areas

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