Imaging cell trafficking and immune cell activation using PET reporter genes

E. D. Nair-Gill, Chengyi J. Shu, Isabel J. Hildebrandt, Dean O. Campbell, Owen N. Witte, Caius G. Radu

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

MAJOR IMMUNE CELL TYPES AND THEIR FUNCTIONS. Pathogen invasion of an immunocompetent host induces a coordinated response from a network of diverse immune cell types. The interactions between these various immune cell types are spatially and temporally regulated to facilitate the acquisition of effector mechanisms that ensure pathogen clearance. This section briefly summarizes the major components of the immune network and their actions during an immune response. A more detailed description of the development and function of specific immune cell types can be found in. The immune network has two major components: the innate and adaptive immune systems. Cells of the innate immune system such as macrophages and dendritic cells generally make first contact with pathogens. Pathogen-derived molecules activate specific receptors on innate immune cells leading to the release of chemo-attractant molecules and recruitment of other inflammatory cells such as neutrophils. Furthermore, macrophages and dendritic cells ingest foreign proteins (or antigens) and migrate to nearby lymph nodes where they serve as antigen-presenting cells (APCs) in the initiation of the adaptive immune response. T and B lymphocytes are the key cell types of the adaptive immune system. Both B and T cells express dedicated and highly variable cell surface receptors for antigen. Exposure to antigen together with help from T cells activates B cells to proliferate and differentiate into plasma cells that secrete antigen-specific antibodies that, by various effector mechanisms participate in antigen clearance. Once the invading pathogen has been cleared, the expanded antigen-specific B cell population contracts through apoptosis.

Original languageEnglish (US)
Title of host publicationMolecular Imaging with Reporter Genes
PublisherCambridge University Press
Pages258-274
Number of pages17
ISBN (Electronic)9780511730405
ISBN (Print)9780521882330
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Reporter Genes
Pathogens
Genes
Chemical activation
Imaging techniques
Antigens
Immune system
B-Lymphocytes
T-cells
Macrophages
Immune System
T-Lymphocytes
Cells
Dendritic Cells
Molecules
Lymphocytes
Cell Surface Receptors
Adaptive Immunity
Antigen-Presenting Cells
Surface Antigens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nair-Gill, E. D., Shu, C. J., Hildebrandt, I. J., Campbell, D. O., Witte, O. N., & Radu, C. G. (2010). Imaging cell trafficking and immune cell activation using PET reporter genes. In Molecular Imaging with Reporter Genes (pp. 258-274). Cambridge University Press. https://doi.org/10.1017/CBO9780511730405.012

Imaging cell trafficking and immune cell activation using PET reporter genes. / Nair-Gill, E. D.; Shu, Chengyi J.; Hildebrandt, Isabel J.; Campbell, Dean O.; Witte, Owen N.; Radu, Caius G.

Molecular Imaging with Reporter Genes. Cambridge University Press, 2010. p. 258-274.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nair-Gill, ED, Shu, CJ, Hildebrandt, IJ, Campbell, DO, Witte, ON & Radu, CG 2010, Imaging cell trafficking and immune cell activation using PET reporter genes. in Molecular Imaging with Reporter Genes. Cambridge University Press, pp. 258-274. https://doi.org/10.1017/CBO9780511730405.012
Nair-Gill ED, Shu CJ, Hildebrandt IJ, Campbell DO, Witte ON, Radu CG. Imaging cell trafficking and immune cell activation using PET reporter genes. In Molecular Imaging with Reporter Genes. Cambridge University Press. 2010. p. 258-274 https://doi.org/10.1017/CBO9780511730405.012
Nair-Gill, E. D. ; Shu, Chengyi J. ; Hildebrandt, Isabel J. ; Campbell, Dean O. ; Witte, Owen N. ; Radu, Caius G. / Imaging cell trafficking and immune cell activation using PET reporter genes. Molecular Imaging with Reporter Genes. Cambridge University Press, 2010. pp. 258-274
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