Imaging gene expression using oligonucleotides and peptide nucleic acids

Zain Paroo, David R. Corey

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The development of methods for non-invasive, real-time imaging of gene expression would provide powerful tools for biomedical research and medical diagnostics. A broadly applicable strategy for achieving this goal is the use of complementary oligonucleotide probes for recognition of mRNA. The major challenge for molecular imaging is the development of specific and efficient transducers for signaling probe-target interaction. This review summarizes the strengths and limitations of reported molecular approaches for imaging of mRNA expression and discusses the challenges to development of in vivo methods.

Original languageEnglish (US)
Pages (from-to)437-442
Number of pages6
JournalJournal of Cellular Biochemistry
Volume90
Issue number3
DOIs
StatePublished - Oct 15 2003

Keywords

  • Antisense
  • MRNA
  • Molecular beacons
  • Molecular imaging
  • Molecular probes
  • PNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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