Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

Xiao Da Li; Xiao Long Liang; Xiu Li Yue; Jin Rui Wang; Chang Hui Li; Zi Jian Deng; Li Jia Jing; Li Lin; En Ze Qu; Shu Min Wang; Chun Long Wu; Hua Xing Wu; Zhi Fei Dai

doi:10.1039/c3tb21281e

Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

Xiao Da Li, Xiao Long Liang, Xiu Li Yue, Jin Rui Wang, Chang Hui Li, Zi Jian Deng, Li Jia Jing, Li Lin, En Ze Qu, Shu Min Wang, Chun Long Wu, Hua Xing Wu, Zhi Fei Dai

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

Original language	English (US)
Pages (from-to)	217-223
Number of pages	7
Journal	Journal of Materials Chemistry B
Volume	2
Issue number	2
DOIs	https://doi.org/10.1039/c3tb21281e
State	Published - Jan 14 2014
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

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title = "Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide",

abstract = "A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.",

author = "Li, {Xiao Da} and Liang, {Xiao Long} and Yue, {Xiu Li} and Wang, {Jin Rui} and Li, {Chang Hui} and Deng, {Zi Jian} and Jing, {Li Jia} and Li Lin and Qu, {En Ze} and Wang, {Shu Min} and Wu, {Chun Long} and Wu, {Hua Xing} and Dai, {Zhi Fei}",

year = "2014",

month = jan,

day = "14",

doi = "10.1039/c3tb21281e",

language = "English (US)",

volume = "2",

pages = "217--223",

journal = "Journal of Materials Chemistry B",

issn = "2050-7518",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

AU - Li, Xiao Da

AU - Liang, Xiao Long

AU - Yue, Xiu Li

AU - Wang, Jin Rui

AU - Li, Chang Hui

AU - Deng, Zi Jian

AU - Jing, Li Jia

AU - Lin, Li

AU - Qu, En Ze

AU - Wang, Shu Min

AU - Wu, Chun Long

AU - Wu, Hua Xing

AU - Dai, Zhi Fei

PY - 2014/1/14

Y1 - 2014/1/14

N2 - A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

AB - A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

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Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

Abstract

ASJC Scopus subject areas

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