Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

Xiao Da Li, Xiao Long Liang, Xiu Li Yue, Jin Rui Wang, Chang Hui Li, Zi Jian Deng, Li Jia Jing, Li Lin, En Ze Qu, Shu Min Wang, Chun Long Wu, Hua Xing Wu, Zhi Fei Dai

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalJournal of Materials Chemistry B
Volume2
Issue number2
DOIs
StatePublished - Jan 14 2014
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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