Imaging hemodynamic effects of ET-1 on cerebral blood flow in rats

Adrien Ponticorvo, W. J. Tom, M. Aura, T. A. Jones, A. K. Dunn

2 Scopus citations

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictor sometimes used in studies of cerebral ischemia. Its ability to create ischemic regions of various sizes with little additional damage has made it a popular tool in evaluating anti-stroke drugs. Despite its emergence in stroke models, it remains poorly characterized. Attempts to do this with Laser Doppler Flowmetry (LDF) or a histological analysis provide good temporal resolution or good spatial resolution respectively, but not both. An imaging modality that provides both temporal and spatial resolution would be able to better characterize the acute and chronic effects of ET-1 on cerebral blood flow. We have used laser speckle contrast imaging to study the effects of ET-1 after topical application on rats. We observed an immediate decrease in blood flow corresponding to the amount of ET-1 used. After the initial decrease, the blood flow slowly increases towards the baseline value with occasional vasospastic responses observed. Future studies involving multi-spectral reflectance imaging combined with the laser speckle contrast analysis would lead to a better understanding of the hemodynamic effects of ET-1.

Original languageEnglish (US)
Title of host publicationBiomedical Applications of Light Scattering
DOIs
StatePublished - 2007
Externally publishedYes
EventBiomedical Applications of Light Scattering - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6446
ISSN (Print)1605-7422

Conference

ConferenceBiomedical Applications of Light Scattering
Country/TerritoryUnited States
CitySan Jose, CA
Period1/20/071/23/07

Keywords

  • Endothelin 1
  • Hemodynamic processes
  • Ischemia
  • Laser speckle contrast imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Imaging hemodynamic effects of ET-1 on cerebral blood flow in rats'. Together they form a unique fingerprint.

Cite this