TY - CHAP
T1 - Imaging in immunology research
AU - Lee, Jason T.
AU - Nair-Gill, Evan D.
AU - Rabinovich, Brian A.
AU - Radu, Caius G.
AU - Witte, Owen N.
N1 - Funding Information:
Supported by the National Institutes of Health, the National Center for Medical Rehabilitation Research (grant no. K01HD01221), and the National Institute of Disability and Rehabilitation Research (grant no. H133A98023).
PY - 2011
Y1 - 2011
N2 - The immune system is central to health and tools to measure its dynamic function are critically needed in research and clinical settings. Molecular imaging modalities such as optical imaging, positron emission tomography (PET), computed tomography, and magnetic resonance imaging enable noninvasive longitudinal studies of immune function throughout the body. In vivo molecular imaging studies in small animals have revealed patterns of immune cell localization, trafficking, and function that cannot be obtained using conventional immune monitoring methods. This chapter reviews applications of optical imaging and PET in the study of immune trafficking and function, models of disease, and cancer immunotherapies with an assessment of the challenges facing the field.
AB - The immune system is central to health and tools to measure its dynamic function are critically needed in research and clinical settings. Molecular imaging modalities such as optical imaging, positron emission tomography (PET), computed tomography, and magnetic resonance imaging enable noninvasive longitudinal studies of immune function throughout the body. In vivo molecular imaging studies in small animals have revealed patterns of immune cell localization, trafficking, and function that cannot be obtained using conventional immune monitoring methods. This chapter reviews applications of optical imaging and PET in the study of immune trafficking and function, models of disease, and cancer immunotherapies with an assessment of the challenges facing the field.
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U2 - 10.1007/978-3-642-12945-2_36
DO - 10.1007/978-3-642-12945-2_36
M3 - Chapter
AN - SCOPUS:84892218342
SN - 9783642129445
SP - 565
EP - 583
BT - Small Animal Imaging
PB - Springer Berlin Heidelberg
ER -