Immature platelets as a biomarker for disease severity and mortality in COVID-19 patients

Daniel Welder, Haekyung Jeon-Slaughter, Bilal Ashraf, Sung Hee Choi, Weina Chen, Ibrahim Ibrahim, Taha Bat

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

COVID-19, caused by SARS-CoV-2, is a contagious life-threatening viral disease that has killed more than three million people worldwide to date. Attempts have been made to identify biomarker(s) to stratify disease severity and improve treatment and resource allocation. Patients with SARS-COV-2 infection manifest with a higher inflammatory response and platelet hyperreactivity; this raises the question of the role of thrombopoiesis in COVID-19 infection. Immature platelet fraction (IPF, %) and immature platelet counts (IPC, ×109/l) can be used to assess thrombopoiesis. This study investigates whether the level of thrombopoiesis correlates with COVID-19 severity. A large cohort of 678 well-characterized COVID-19 patients was analyzed, including 658 (97%) hospitalized and 139 (21%) admitted to the intensive care unit (ICU). Elevated percentage IPF at presentation was predictive of length of hospitalization (P < 0·01) and ICU admission (P < 0·05). Additionally, percentage IPF at the peak was significantly higher among ICU patients than non-ICU patients (6·9 ± 5·1 vs 5·3 ± 8·4, P < 0·01) and among deceased patients than recovered patients (7·9 ± 6·3 vs 5·4 ± 7·8, P < 0·01). Furthermore, IPC at the peak was significantly higher among ICU patients than non-ICU patients (18·5 ± 16·2 vs. 13·2 ± 8·3, P < 0·05) and among patients on a ventilator than those not (22·1 ± 20·1 vs.13·4 ± 8·4, P < 0·05). Our study demonstrated that elevated initial and peak values of percentage IPF and IPC might serve as prognostic biomarkers for COVID-19 progression to severe conditions.

Original languageEnglish (US)
Pages (from-to)530-536
Number of pages7
JournalBritish Journal of Haematology
Volume194
Issue number3
DOIs
StatePublished - Aug 2021

Keywords

  • COVID-19
  • IPF
  • biomarker
  • immature platelet
  • reticulated platelets

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Immature platelets as a biomarker for disease severity and mortality in COVID-19 patients'. Together they form a unique fingerprint.

Cite this