Immune adaptations that maintain homeostasis with the intestinal microbiota

Lora V. Hooper, Andrew J. MacPherson

Research output: Contribution to journalReview articlepeer-review

762 Scopus citations

Abstract

Humans harbour nearly 100 trillion intestinal bacteria that are essential for health. Millions of years of co-evolution have moulded this human-microorganism interaction into a symbiotic relationship in which gut bacteria make essential contributions to human nutrient metabolism and in return occupy a nutrient-rich environment. Although intestinal microorganisms carry out essential functions for their hosts, they pose a constant threat of invasion owing to their sheer numbers and the large intestinal surface area. In this Review, we discuss the unique adaptations of the intestinal immune system that maintain homeostatic interactions with a diverse resident microbiota.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalNature Reviews Immunology
Volume10
Issue number3
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Immune adaptations that maintain homeostasis with the intestinal microbiota'. Together they form a unique fingerprint.

Cite this