TY - JOUR
T1 - Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection
AU - Aurora, Arin B.
AU - Baluk, Peter
AU - Zhang, DongJi
AU - Sidhu, Sukhvinder S.
AU - Dolganov, Gregory M.
AU - Basbaum, Carol
AU - McDonald, Donald M.
AU - Killeen, Nigel
PY - 2005/11/15
Y1 - 2005/11/15
N2 - Chronic inflammation in the airways is associated with dramatic architectural changes in the walls of the airways and in the vasculature they contain. In this study, we show that the adaptive immune system is essential for airway remodeling that occurs in mice that are chronically infected with the respiratory pathogen Mycoplasma pulmonis. Angiogenesis, lymphangiogenesis, and epithelial remodeling were greatly reduced in mice that lacked B cells. Substantiating a role for Ab and airway immune complexes, we found that the transfer of immune serum to B cell-deficient mice could reconstitute pathogen-induced angiogenesis. Inflammatory cells recruited to the infected airways were activated by the humoral response, and this activation correlated with the induction of genes for remodeling factors such as vascular endothelial growth factor-D. The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology.
AB - Chronic inflammation in the airways is associated with dramatic architectural changes in the walls of the airways and in the vasculature they contain. In this study, we show that the adaptive immune system is essential for airway remodeling that occurs in mice that are chronically infected with the respiratory pathogen Mycoplasma pulmonis. Angiogenesis, lymphangiogenesis, and epithelial remodeling were greatly reduced in mice that lacked B cells. Substantiating a role for Ab and airway immune complexes, we found that the transfer of immune serum to B cell-deficient mice could reconstitute pathogen-induced angiogenesis. Inflammatory cells recruited to the infected airways were activated by the humoral response, and this activation correlated with the induction of genes for remodeling factors such as vascular endothelial growth factor-D. The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology.
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U2 - 10.4049/jimmunol.175.10.6319
DO - 10.4049/jimmunol.175.10.6319
M3 - Article
C2 - 16272283
AN - SCOPUS:27744475046
SN - 0022-1767
VL - 175
SP - 6319
EP - 6326
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -