Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection

Arin B. Aurora, Peter Baluk, DongJi Zhang, Sukhvinder S. Sidhu, Gregory M. Dolganov, Carol Basbaum, Donald M. McDonald, Nigel Killeen

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Chronic inflammation in the airways is associated with dramatic architectural changes in the walls of the airways and in the vasculature they contain. In this study, we show that the adaptive immune system is essential for airway remodeling that occurs in mice that are chronically infected with the respiratory pathogen Mycoplasma pulmonis. Angiogenesis, lymphangiogenesis, and epithelial remodeling were greatly reduced in mice that lacked B cells. Substantiating a role for Ab and airway immune complexes, we found that the transfer of immune serum to B cell-deficient mice could reconstitute pathogen-induced angiogenesis. Inflammatory cells recruited to the infected airways were activated by the humoral response, and this activation correlated with the induction of genes for remodeling factors such as vascular endothelial growth factor-D. The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology.

Original languageEnglish (US)
Pages (from-to)6319-6326
Number of pages8
JournalJournal of Immunology
Volume175
Issue number10
StatePublished - Nov 15 2005

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Airway Remodeling
Antigen-Antibody Complex
Bacterial Infections
Lymphangiogenesis
B-Lymphocytes
Mycoplasma pulmonis
Vascular Endothelial Growth Factor D
Inflammation
Humoral Immunity
Immune Sera
Immune System
Pathology
T-Lymphocytes
Infection
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Aurora, A. B., Baluk, P., Zhang, D., Sidhu, S. S., Dolganov, G. M., Basbaum, C., ... Killeen, N. (2005). Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. Journal of Immunology, 175(10), 6319-6326.

Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. / Aurora, Arin B.; Baluk, Peter; Zhang, DongJi; Sidhu, Sukhvinder S.; Dolganov, Gregory M.; Basbaum, Carol; McDonald, Donald M.; Killeen, Nigel.

In: Journal of Immunology, Vol. 175, No. 10, 15.11.2005, p. 6319-6326.

Research output: Contribution to journalArticle

Aurora, AB, Baluk, P, Zhang, D, Sidhu, SS, Dolganov, GM, Basbaum, C, McDonald, DM & Killeen, N 2005, 'Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection', Journal of Immunology, vol. 175, no. 10, pp. 6319-6326.
Aurora AB, Baluk P, Zhang D, Sidhu SS, Dolganov GM, Basbaum C et al. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. Journal of Immunology. 2005 Nov 15;175(10):6319-6326.
Aurora, Arin B. ; Baluk, Peter ; Zhang, DongJi ; Sidhu, Sukhvinder S. ; Dolganov, Gregory M. ; Basbaum, Carol ; McDonald, Donald M. ; Killeen, Nigel. / Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. In: Journal of Immunology. 2005 ; Vol. 175, No. 10. pp. 6319-6326.
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