TY - JOUR
T1 - Immune modulation of stem cells and regeneration
AU - Aurora, Arin B.
AU - Olson, Eric N.
N1 - Funding Information:
We are grateful to Jose Cabrera for graphics. We apologize to authors whose papers we could not cite due to space limitations. Work in the laboratory of E.N.O. is supported by grants from the NIH (HL-077439, HL-111665, HL-093039, DK-099653, and U01-HL-100401), Foundation Leducq Networks of Excellence, the Cancer Prevention and Research Institute of Texas, and the Robert A. Welch Foundation (grant 1-0025 to E.N.O.).
PY - 2014/7/3
Y1 - 2014/7/3
N2 - The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement after injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.
AB - The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement after injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.
UR - http://www.scopus.com/inward/record.url?scp=84904006242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904006242&partnerID=8YFLogxK
U2 - 10.1016/j.stem.2014.06.009
DO - 10.1016/j.stem.2014.06.009
M3 - Review article
C2 - 24996166
AN - SCOPUS:84904006242
SN - 1934-5909
VL - 15
SP - 14
EP - 25
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 1
ER -