Immunobiology of age-related macular degeneration

Rafael L. Ufret-Vincenty, Sarah L. Doyle

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite recent therapeutic advances, clinical outcomes of both neovascular and atrophic age-related macular degeneration (AMD) remain suboptimal. This article reviews evidence supporting the concept that the immune system plays an important role in the pathogenesis of AMD. This includes genetic results, histopathology data, serological data, and observations in animal models. It is important to recognize the immaturity of our knowledge and the need to expand our understanding of the early pathologic events in AMD, with the goal of identifying new strategies to prevent rather than treat the disease. The immune system will likely provide new therapeutic targets.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages279-284
Number of pages6
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • AMD
  • ARMD
  • Age-related macular degeneration
  • C-reactive protein
  • CNV
  • Choroidal neovascularization
  • Complement factor H
  • Drusen
  • Geographic atrophy
  • Histopathology
  • Immune system
  • Immunopathology
  • Inflammation
  • Macrophages
  • NLRP3-Inflammasome
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Ufret-Vincenty, R. L., & Doyle, S. L. (2016). Immunobiology of age-related macular degeneration. In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology (pp. 279-284). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-809324-5.01388-2