Immunocyte membrane-coated nanoparticles for cancer immunotherapy

Ping Gong, Yifan Wang, Pengfei Zhang, Zhaogang Yang, Weiye Deng, Zhihong Sun, Mingming Yang, Xuefeng Li, Gongcheng Ma, Guanjun Deng, Shiyan Dong, Lintao Cai, Wen Jiang

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite the advances in surface bioconjugation of synthetic nanoparticles for targeted drug delivery, simple biological functionalization is still insufficient to replicate complex intercellular interactions naturally. Therefore, these foreign nanoparticles are inevitably exposed to the immune system, which results in phagocytosis by the reticuloendothelial system and thus, loss of their biological significance. Immunocyte membranes play a key role in intercellular interactions, and can protect foreign nanomaterials as a natural barrier. Therefore, biomimetic nanotechnology based on cell membranes has developed rapidly in recent years. This paper summarizes the development of immunocyte membrane-coated nanoparticles in the immunotherapy of tumors. We will introduce several immunocyte membrane-coated nanocarriers and review the challenges to their large-scale preparation and application.

Original languageEnglish (US)
Article number77
Pages (from-to)1-17
Number of pages17
JournalCancers
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2021

Keywords

  • Biomimicry
  • Cancer immunotherapy
  • Dendritic cell
  • Immunocyte membrane-coated nanoparticles
  • Macrophage
  • Natural killer
  • T-cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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