Immunogenetic basis for immunologic privilege in the anterior chamber of the eye

Jerry Y. Niederkorn, John A. Shadduck, J. Wayne Streilein

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

DBA/2 mastocytoma (P815) cells are able to grow when inoculated into the anterior chamber of eyes of histoincompatible mice. Tumor growth is unrestrained in recipient mice differing from the DBA/2 strain at multiple minor H loci, but sharing the H-2d haplotype; progressive tumor growth in these animals involves the entire eye, invades the orbit and kills the hosts by extension into the cranial vault. Alternatively, P815 cells grow initially but are unable to sustain continued growth in the anterior chambers of recipient mice differing from DBA/2 at the H-2 complex. Recipients differing from DBA/2 at either the K or D regions of H-2 develop anti-DBA/2 immunity that destroys the intraocular tumor within 20 days of inoculation. Severe inflammatory reactions in these eyes produce "innocent bystander" destruction of ocular tissue and produce blindness. Recipients differing from DBA/2 at both K and D regions of H-2 also mount vigorous anti-DBA/2 immunity that destroys the intraocular tumor. In these instances, the nonspecific component of the rejection reaction is minimal: when the tumor cells are destroyed, the eyes are restored to anatomic and functional integrity. These results indicate that immunologic privilege in the anterior chamber of the eye is afforded to allogeneic tissues to varing degrees depending upon allodisparity at H-2 loci encoding class I MHC products. The results further imply that the precision of the alloimmune response may be under the control of these same MHC products.

Original languageEnglish (US)
Pages (from-to)227-236
Number of pages10
JournalImmunogenetics
Volume13
Issue number3
DOIs
StatePublished - May 1981

Fingerprint

Immunogenetics
Anterior Chamber
Inbred DBA Mouse
Neoplasms
Immunity
Growth
Mastocytoma
Orbit
Blindness
Haplotypes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Immunogenetic basis for immunologic privilege in the anterior chamber of the eye. / Niederkorn, Jerry Y.; Shadduck, John A.; Streilein, J. Wayne.

In: Immunogenetics, Vol. 13, No. 3, 05.1981, p. 227-236.

Research output: Contribution to journalArticle

Niederkorn, Jerry Y. ; Shadduck, John A. ; Streilein, J. Wayne. / Immunogenetic basis for immunologic privilege in the anterior chamber of the eye. In: Immunogenetics. 1981 ; Vol. 13, No. 3. pp. 227-236.
@article{49d23a4b198e4990b152599fa8b13d7b,
title = "Immunogenetic basis for immunologic privilege in the anterior chamber of the eye",
abstract = "DBA/2 mastocytoma (P815) cells are able to grow when inoculated into the anterior chamber of eyes of histoincompatible mice. Tumor growth is unrestrained in recipient mice differing from the DBA/2 strain at multiple minor H loci, but sharing the H-2d haplotype; progressive tumor growth in these animals involves the entire eye, invades the orbit and kills the hosts by extension into the cranial vault. Alternatively, P815 cells grow initially but are unable to sustain continued growth in the anterior chambers of recipient mice differing from DBA/2 at the H-2 complex. Recipients differing from DBA/2 at either the K or D regions of H-2 develop anti-DBA/2 immunity that destroys the intraocular tumor within 20 days of inoculation. Severe inflammatory reactions in these eyes produce {"}innocent bystander{"} destruction of ocular tissue and produce blindness. Recipients differing from DBA/2 at both K and D regions of H-2 also mount vigorous anti-DBA/2 immunity that destroys the intraocular tumor. In these instances, the nonspecific component of the rejection reaction is minimal: when the tumor cells are destroyed, the eyes are restored to anatomic and functional integrity. These results indicate that immunologic privilege in the anterior chamber of the eye is afforded to allogeneic tissues to varing degrees depending upon allodisparity at H-2 loci encoding class I MHC products. The results further imply that the precision of the alloimmune response may be under the control of these same MHC products.",
author = "Niederkorn, {Jerry Y.} and Shadduck, {John A.} and Streilein, {J. Wayne}",
year = "1981",
month = "5",
doi = "10.1007/BF00350789",
language = "English (US)",
volume = "13",
pages = "227--236",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Immunogenetic basis for immunologic privilege in the anterior chamber of the eye

AU - Niederkorn, Jerry Y.

AU - Shadduck, John A.

AU - Streilein, J. Wayne

PY - 1981/5

Y1 - 1981/5

N2 - DBA/2 mastocytoma (P815) cells are able to grow when inoculated into the anterior chamber of eyes of histoincompatible mice. Tumor growth is unrestrained in recipient mice differing from the DBA/2 strain at multiple minor H loci, but sharing the H-2d haplotype; progressive tumor growth in these animals involves the entire eye, invades the orbit and kills the hosts by extension into the cranial vault. Alternatively, P815 cells grow initially but are unable to sustain continued growth in the anterior chambers of recipient mice differing from DBA/2 at the H-2 complex. Recipients differing from DBA/2 at either the K or D regions of H-2 develop anti-DBA/2 immunity that destroys the intraocular tumor within 20 days of inoculation. Severe inflammatory reactions in these eyes produce "innocent bystander" destruction of ocular tissue and produce blindness. Recipients differing from DBA/2 at both K and D regions of H-2 also mount vigorous anti-DBA/2 immunity that destroys the intraocular tumor. In these instances, the nonspecific component of the rejection reaction is minimal: when the tumor cells are destroyed, the eyes are restored to anatomic and functional integrity. These results indicate that immunologic privilege in the anterior chamber of the eye is afforded to allogeneic tissues to varing degrees depending upon allodisparity at H-2 loci encoding class I MHC products. The results further imply that the precision of the alloimmune response may be under the control of these same MHC products.

AB - DBA/2 mastocytoma (P815) cells are able to grow when inoculated into the anterior chamber of eyes of histoincompatible mice. Tumor growth is unrestrained in recipient mice differing from the DBA/2 strain at multiple minor H loci, but sharing the H-2d haplotype; progressive tumor growth in these animals involves the entire eye, invades the orbit and kills the hosts by extension into the cranial vault. Alternatively, P815 cells grow initially but are unable to sustain continued growth in the anterior chambers of recipient mice differing from DBA/2 at the H-2 complex. Recipients differing from DBA/2 at either the K or D regions of H-2 develop anti-DBA/2 immunity that destroys the intraocular tumor within 20 days of inoculation. Severe inflammatory reactions in these eyes produce "innocent bystander" destruction of ocular tissue and produce blindness. Recipients differing from DBA/2 at both K and D regions of H-2 also mount vigorous anti-DBA/2 immunity that destroys the intraocular tumor. In these instances, the nonspecific component of the rejection reaction is minimal: when the tumor cells are destroyed, the eyes are restored to anatomic and functional integrity. These results indicate that immunologic privilege in the anterior chamber of the eye is afforded to allogeneic tissues to varing degrees depending upon allodisparity at H-2 loci encoding class I MHC products. The results further imply that the precision of the alloimmune response may be under the control of these same MHC products.

UR - http://www.scopus.com/inward/record.url?scp=0019407759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019407759&partnerID=8YFLogxK

U2 - 10.1007/BF00350789

DO - 10.1007/BF00350789

M3 - Article

VL - 13

SP - 227

EP - 236

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 3

ER -