Immunogenetics of rheumatoid arthritis and juvenile arthritis.

P. Stastny, X. J. Gao, M. Fernandez-Viña

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Starting with the historical background and ending with the most recent data obtained by DNA typing, using PCR and oligonucleotide probes, the role of HLA antigens in rheumatoid arthritis (RA) and in several forms of juvenile arthritis (JA) is reviewed. RA is thought to be associated with an epitope of the third hypervariable region of DRB1 which is shared by several alleles including DR4-Dw4, Dw14, Dw15, DR1, DRw14.2, and DRw10. Rheumatoid factor-positive JA is also associated with DR4, but in rheumatoid factor-negative JA DR4 is absent, or markedly decreased, suggesting that it has a protective effect. Typing for the HLA-DP alleles has confirmed the association of pauciarticular JA with DPBI*0201. Recent studies in the author's laboratory have shown that DPB1*0301 is the main susceptibility factor for rheumatoid factor-negative polyarticular onset JA. It is of interest that also adult rheumatoid factor-negative RA patients have an increase of DPB1*0301, suggesting that these two clinical subsets may represent related diseases.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalRecenti Progressi in Medicina
Volume82
Issue number7-8
StatePublished - Jul 1991

Fingerprint

Immunogenetics
Juvenile Arthritis
Rheumatoid Factor
Rheumatoid Arthritis
Alleles
HLA-DP Antigens
DNA Fingerprinting
Oligonucleotide Probes
HLA Antigens
Epitopes
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stastny, P., Gao, X. J., & Fernandez-Viña, M. (1991). Immunogenetics of rheumatoid arthritis and juvenile arthritis. Recenti Progressi in Medicina, 82(7-8), 409-416.

Immunogenetics of rheumatoid arthritis and juvenile arthritis. / Stastny, P.; Gao, X. J.; Fernandez-Viña, M.

In: Recenti Progressi in Medicina, Vol. 82, No. 7-8, 07.1991, p. 409-416.

Research output: Contribution to journalArticle

Stastny, P, Gao, XJ & Fernandez-Viña, M 1991, 'Immunogenetics of rheumatoid arthritis and juvenile arthritis.', Recenti Progressi in Medicina, vol. 82, no. 7-8, pp. 409-416.
Stastny P, Gao XJ, Fernandez-Viña M. Immunogenetics of rheumatoid arthritis and juvenile arthritis. Recenti Progressi in Medicina. 1991 Jul;82(7-8):409-416.
Stastny, P. ; Gao, X. J. ; Fernandez-Viña, M. / Immunogenetics of rheumatoid arthritis and juvenile arthritis. In: Recenti Progressi in Medicina. 1991 ; Vol. 82, No. 7-8. pp. 409-416.
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