Immunogenicity and immune privilege of corneal allografts

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations

Abstract

Corneal allografts enjoy a remarkable success rate when compared to all other forms of organ transplants. In routine keratoplasties, HLA matching and systemic immunosuppressive drugs are not employed, yet 90% of the uncomplicated transplants survive. The success of corneal allografts was recognized over half a century ago and led to the term 'immune privilege'. The original explanation for the immune privilege of corneal allografts attributed the escape of immune rejection to the avascular and alymphatic nature of the corneal graft bed, which sequestered the corneal allograft from the immune apparatus. In the past 20 years, the widespread use of animal models of keratoplasty has shed light on the mechanisms of corneal immune privilege and has revealed that the success of corneal allografts is due to a combination of properties of the corneal graft bed and the cornea itself.

Original languageEnglish (US)
Title of host publicationImmune Response and the Eye
EditorsJerry Niederkorn, Henry Kaplan
Pages290-299
Number of pages10
DOIs
StatePublished - Jul 30 2007

Publication series

NameChemical Immunology and Allergy
Volume92
ISSN (Print)1660-2242

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Hori, J., & Niederkorn, J. Y. (2007). Immunogenicity and immune privilege of corneal allografts. In J. Niederkorn, & H. Kaplan (Eds.), Immune Response and the Eye (pp. 290-299). (Chemical Immunology and Allergy; Vol. 92). https://doi.org/10.1159/000099279