Immunogenicity of novel consensus-based DNA vaccines against avian influenza

Dominick J. Laddy, Jian Yan, Natasha Corbitt, Darwyn Kobasa, Gary P. Kobinger, David B. Weiner

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

The frequency of H5N1 avian influenza outbreaks in China and Eastern Europe has raised concern in the world health community regarding the potential for an influenza pandemic. Efforts to monitor the disease will only provide minimal warning in a global society, and steps must be taken to prevent the morbidity and mortality associated with past pandemics. The current stockpiling of antibody-inducing "bird flu" vaccines assumes the strain that emerges will be the same as strains currently circulating. We propose a novel consensus-based approach to vaccine development, employing a DNA vaccine strategy that can provide more highly cross-reactive cellular immunity against lethal influenza infection. We show such constructs can induce strong cellular immunity against H5 influenza antigens.

Original languageEnglish (US)
Pages (from-to)2984-2989
Number of pages6
JournalVaccine
Volume25
Issue number16 SPEC. ISS.
DOIs
StatePublished - Apr 20 2007
Externally publishedYes

Keywords

  • Avian influenza
  • Consensus
  • DNA vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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