Immunohistochemical expression of β-catenin in solitary fibrous tumors

Dinesh Rakheja, Kyle H Molberg, Cory A. Roberts, Vilkesh R. Jaiswal

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Context. - Immunohistochemical staining for β-catenin may be used as an indicator of the integrity of the Wnt signaling and β-catenin degradation pathways. Among mesenchymal tumors, aberrant nuclear localization of β-catenin is seen in desmoid-type fibromatoses but has not been described for solitary fibrous tumors that may mimic the former lesions, especially in small biopsy samples. Objective. - To study the immunohistochemical expression of β-catenin in solitary fibrous tumors. Design. - We performed immunohistochemical staining for β-catenin in 12 solitary fibrous tumors, one of which showed histologic features of malignancy. Results. - All the tumors showed strong and diffuse reactivity for β-catenin. Four tumors (33%) showed nuclear staining for β-catenin, whereas the remaining tumors showed either a membranous or mixed membranous and cytoplasmic pattern of staining. The only histologically malignant tumor of the group showed a mixed membranous and cytoplasmic pattern of staining for β-catenin. Conclusions. - Immunohistochemical staining for β-catenin in solitary fibrous tumors does not show a consistent pattern, which may be due to differences in tumorigenesis. Larger studies with clinical follow-up are required for estimating the impact of the variable staining pattern on clinical behavior of these tumors.

Original languageEnglish (US)
Pages (from-to)776-779
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume129
Issue number6
StatePublished - Jun 2005

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Solitary Fibrous Tumors
Catenins
Staining and Labeling
Neoplasms
Aggressive Fibromatosis
Fibroma
Carcinogenesis
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Immunohistochemical expression of β-catenin in solitary fibrous tumors. / Rakheja, Dinesh; Molberg, Kyle H; Roberts, Cory A.; Jaiswal, Vilkesh R.

In: Archives of Pathology and Laboratory Medicine, Vol. 129, No. 6, 06.2005, p. 776-779.

Research output: Contribution to journalArticle

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abstract = "Context. - Immunohistochemical staining for β-catenin may be used as an indicator of the integrity of the Wnt signaling and β-catenin degradation pathways. Among mesenchymal tumors, aberrant nuclear localization of β-catenin is seen in desmoid-type fibromatoses but has not been described for solitary fibrous tumors that may mimic the former lesions, especially in small biopsy samples. Objective. - To study the immunohistochemical expression of β-catenin in solitary fibrous tumors. Design. - We performed immunohistochemical staining for β-catenin in 12 solitary fibrous tumors, one of which showed histologic features of malignancy. Results. - All the tumors showed strong and diffuse reactivity for β-catenin. Four tumors (33{\%}) showed nuclear staining for β-catenin, whereas the remaining tumors showed either a membranous or mixed membranous and cytoplasmic pattern of staining. The only histologically malignant tumor of the group showed a mixed membranous and cytoplasmic pattern of staining for β-catenin. Conclusions. - Immunohistochemical staining for β-catenin in solitary fibrous tumors does not show a consistent pattern, which may be due to differences in tumorigenesis. Larger studies with clinical follow-up are required for estimating the impact of the variable staining pattern on clinical behavior of these tumors.",
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