Immunohistochemical expression of neural cell adhesion molecule in wilms tumors, nephrogenic rests, and fetal and postnatal renal cortices

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4 Scopus citations

Abstract

Neural cell adhesion molecule (NCAM) has been suggested to be a marker for stem cells and progenitor cells in human fetal kidney and Wilms tumors. In this tissue microarray-based immunohistochemical study, we confirmed the expression of NCAM in Wilms tumors, nephrogenic rests, and metanephric mesenchyme and its early derivatives in fetal renal cortex. Neural cell adhesion molecule expression was noted in both favorable-histology and unfavorable-histology Wilms tumors. This indicates that NCAM may be an attractive therapeutic target in chemoresistant, high-risk Wilms tumors. In addition, we saw rare NCAM-positive interstitial stromal cells in postnatal kidney. It is not known if these persistent NCAM-positive interstitial cells might give rise to adult Wilms tumors and cases of pediatric Wilms tumors noth associated with nephrogenic rests.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalPediatric and Developmental Pathology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Kidney
  • NCAM
  • NCAM1
  • Nephrogenic rest
  • Neural cell adhesion molecule
  • Wilms tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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