Immunology and immunomodulation of corneal transplantation

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Corneal allografts are the oldest, most common, and most successful transplants performed on humans and animals. The cornea is endowed with a constellation of unique factors that contribute to its immune privilege and the low incidence of immune rejection. In spite of this immune privilege, 10 percent of first-time corneal grafts will undergo immune rejection. Several novel therapeutic strategies hold promise for modulating the alloimmune response by either promoting antigen-specific tolerance or redirecting the host's response from a Th1 pathway toward a Th2 pathway.

Original languageEnglish (US)
Pages (from-to)173-196
Number of pages24
JournalInternational Reviews of Immunology
Volume21
Issue number2-3
DOIs
StatePublished - Aug 1 2002

Keywords

  • Cornea
  • Immune modulation
  • Immune privilege
  • Keratoplasty
  • Rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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