Immunoneutralization of substance P attenuates the reflex pressor response to muscular contraction

Marc P. Kaufman, Kenneth J. Rybicki, Gerald P. Kozlowski, Gary A. Iwamoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We previously reported that subarachnoid injection of a peptide antagonist to substance P attenuated by half the reflex pressor response to static muscular contraction. Subsequently, some of the peptide antagonists to substance P have been found to possess local anesthetic effects. Therefore, we have repeated our experiments using a substance P antiserum, which was shown to be without local anesthetic effect. We found that intrathecal injection of the antiserum attenuated by more than half the reflex pressor response to static contraction of the triceps surae muscles of cats.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalBrain Research
Volume377
Issue number1
DOIs
StatePublished - Jul 2 1986

Fingerprint

Substance P
Muscle Contraction
Reflex
Local Anesthetics
Anesthetics
Immune Sera
Spinal Injections
Peptides
Cats
Muscles
Injections

Keywords

  • antiserum
  • exercise
  • muscle afferent
  • reflex cardiovascular control
  • spinal cord

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Immunoneutralization of substance P attenuates the reflex pressor response to muscular contraction. / Kaufman, Marc P.; Rybicki, Kenneth J.; Kozlowski, Gerald P.; Iwamoto, Gary A.

In: Brain Research, Vol. 377, No. 1, 02.07.1986, p. 199-203.

Research output: Contribution to journalArticle

Kaufman, Marc P. ; Rybicki, Kenneth J. ; Kozlowski, Gerald P. ; Iwamoto, Gary A. / Immunoneutralization of substance P attenuates the reflex pressor response to muscular contraction. In: Brain Research. 1986 ; Vol. 377, No. 1. pp. 199-203.
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