Immunoneutralization of substance P attenuates the reflex pressor response to muscular contraction

Marc P. Kaufman, Kenneth J. Rybicki, Gerald P. Kozlowski, Gary A. Iwamoto

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We previously reported that subarachnoid injection of a peptide antagonist to substance P attenuated by half the reflex pressor response to static muscular contraction. Subsequently, some of the peptide antagonists to substance P have been found to possess local anesthetic effects. Therefore, we have repeated our experiments using a substance P antiserum, which was shown to be without local anesthetic effect. We found that intrathecal injection of the antiserum attenuated by more than half the reflex pressor response to static contraction of the triceps surae muscles of cats.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalBrain Research
Volume377
Issue number1
DOIs
StatePublished - Jul 2 1986

Keywords

  • antiserum
  • exercise
  • muscle afferent
  • reflex cardiovascular control
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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