IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN

EricJ Hansen, PaulA Gulig, StellaM Robertson, CarolynF Frisch, ElizabethJ Haanes

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.

Original languageEnglish (US)
Pages (from-to)366-368
Number of pages3
JournalThe Lancet
Volume319
Issue number8268
DOIs
StatePublished - Feb 13 1982

Fingerprint

Haemophilus
Haemophilus influenzae type b
Membrane Proteins
Monoclonal Antibodies
Haemophilus Vaccines
Antibodies
Intraperitoneal Injections
Epitopes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN. / Hansen, EricJ; Gulig, PaulA; Robertson, StellaM; Frisch, CarolynF; Haanes, ElizabethJ.

In: The Lancet, Vol. 319, No. 8268, 13.02.1982, p. 366-368.

Research output: Contribution to journalArticle

Hansen, EricJ ; Gulig, PaulA ; Robertson, StellaM ; Frisch, CarolynF ; Haanes, ElizabethJ. / IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN. In: The Lancet. 1982 ; Vol. 319, No. 8268. pp. 366-368.
@article{45504ebae399401f86e176b870eb0940,
title = "IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN",
abstract = "Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.",
author = "EricJ Hansen and PaulA Gulig and StellaM Robertson and CarolynF Frisch and ElizabethJ Haanes",
year = "1982",
month = "2",
day = "13",
doi = "10.1016/S0140-6736(82)91394-0",
language = "English (US)",
volume = "319",
pages = "366--368",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8268",

}

TY - JOUR

T1 - IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN

AU - Hansen, EricJ

AU - Gulig, PaulA

AU - Robertson, StellaM

AU - Frisch, CarolynF

AU - Haanes, ElizabethJ

PY - 1982/2/13

Y1 - 1982/2/13

N2 - Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.

AB - Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.

UR - http://www.scopus.com/inward/record.url?scp=0020060769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020060769&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(82)91394-0

DO - 10.1016/S0140-6736(82)91394-0

M3 - Article

C2 - 6120351

AN - SCOPUS:0020060769

VL - 319

SP - 366

EP - 368

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8268

ER -