Immunoregulation on the ocular surface: 2nd cullen symposium

Stephen C. Pflugfelder; Michael E. Stern; Bruce A. Beutler; Alan R. Burns; Margarita Calonge; James Chodosh; M. Reza Dana; Cintia S. De Paiva; Susanne Fleiszig; Linda D. Hazlett; Andrew J. Huang; Dan B. Jones; Yong Jun Liu; Allison M. McDermott; Austin K. Mircheff; Jerry Y. Niederkorn; Victor Perez; Eric Perlman; Jim Rosenbaum; Argyrios Theofilopoulus; Kirk Wilhelmu

doi:10.1016/S1542-0124(12)70297-5

Immunoregulation on the ocular surface: 2nd cullen symposium

Stephen C. Pflugfelder, Michael E. Stern, Bruce A. Beutler, Alan R. Burns, Margarita Calonge, James Chodosh, M. Reza Dana, Cintia S. De Paiva, Susanne Fleiszig, Linda D. Hazlett, Andrew J. Huang, Dan B. Jones, Yong Jun Liu, Allison M. McDermott, Austin K. Mircheff, Jerry Y. Niederkorn, Victor Perez, Eric Perlman, Jim Rosenbaum, Argyrios TheofilopoulusKirk Wilhelmu

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33 Scopus citations

Abstract

A one-day symposium with 20 invited participants was held to review current knowledge regarding immunoregulation in the ocular surface and cornea. The program consisted of 11 lectures on various aspects of ocular and systemic immunoregulation, followed by a group discussion to formulate regulatory pathways. The ocular surface and its secondary lymphoid tissues contain numerous components of the innate and adaptive immune systems, which modulate the immune response to suppress or prevent excessive damaging immune reactions. These include factors that regulate induction of the immune response (afferent loop), as well as effector cells and soluble factors (efferent loop). The ocular surface is an immunologically active mucosal site that contains numerous mechanisms to regulate the immune response to prevent tissue destruction and vision loss.

Original language	English (US)
Pages (from-to)	67-77
Number of pages	11
Journal	Ocular Surface
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S1542-0124(12)70297-5
State	Published - 2009

Keywords

Antigen-presenting cells
Autoimmune reaction
Immunoregulatory systems
Inflammation
Regulatory T cells
Toll-like receptors

ASJC Scopus subject areas

Ophthalmology

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10.1016/S1542-0124(12)70297-5

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Pflugfelder, S. C., Stern, M. E., Beutler, B. A., Burns, A. R., Calonge, M., Chodosh, J., Dana, M. R., De Paiva, C. S., Fleiszig, S., Hazlett, L. D., Huang, A. J., Jones, D. B., Liu, Y. J., McDermott, A. M., Mircheff, A. K., Niederkorn, J. Y., Perez, V., Perlman, E., Rosenbaum, J., ... Wilhelmu, K. (2009). Immunoregulation on the ocular surface: 2nd cullen symposium. Ocular Surface, 7(2), 67-77. https://doi.org/10.1016/S1542-0124(12)70297-5

Pflugfelder, SC, Stern, ME, Beutler, BA, Burns, AR, Calonge, M, Chodosh, J, Dana, MR, De Paiva, CS, Fleiszig, S, Hazlett, LD, Huang, AJ, Jones, DB, Liu, YJ, McDermott, AM, Mircheff, AK, Niederkorn, JY, Perez, V, Perlman, E, Rosenbaum, J, Theofilopoulus, A & Wilhelmu, K 2009, 'Immunoregulation on the ocular surface: 2nd cullen symposium', Ocular Surface, vol. 7, no. 2, pp. 67-77. https://doi.org/10.1016/S1542-0124(12)70297-5

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title = "Immunoregulation on the ocular surface: 2nd cullen symposium",

abstract = "A one-day symposium with 20 invited participants was held to review current knowledge regarding immunoregulation in the ocular surface and cornea. The program consisted of 11 lectures on various aspects of ocular and systemic immunoregulation, followed by a group discussion to formulate regulatory pathways. The ocular surface and its secondary lymphoid tissues contain numerous components of the innate and adaptive immune systems, which modulate the immune response to suppress or prevent excessive damaging immune reactions. These include factors that regulate induction of the immune response (afferent loop), as well as effector cells and soluble factors (efferent loop). The ocular surface is an immunologically active mucosal site that contains numerous mechanisms to regulate the immune response to prevent tissue destruction and vision loss.",

keywords = "Antigen-presenting cells, Autoimmune reaction, Immunoregulatory systems, Inflammation, Regulatory T cells, Toll-like receptors",

author = "Pflugfelder, {Stephen C.} and Stern, {Michael E.} and Beutler, {Bruce A.} and Burns, {Alan R.} and Margarita Calonge and James Chodosh and Dana, {M. Reza} and {De Paiva}, {Cintia S.} and Susanne Fleiszig and Hazlett, {Linda D.} and Huang, {Andrew J.} and Jones, {Dan B.} and Liu, {Yong Jun} and McDermott, {Allison M.} and Mircheff, {Austin K.} and Niederkorn, {Jerry Y.} and Victor Perez and Eric Perlman and Jim Rosenbaum and Argyrios Theofilopoulus and Kirk Wilhelmu",

note = "Funding Information: Supported in part by an unrestricted grant from Allergan, Inc, Irvine, CA.",

year = "2009",

doi = "10.1016/S1542-0124(12)70297-5",

language = "English (US)",

volume = "7",

pages = "67--77",

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AU - Pflugfelder, Stephen C.

AU - Stern, Michael E.

AU - Beutler, Bruce A.

AU - Burns, Alan R.

AU - Calonge, Margarita

AU - Chodosh, James

AU - Dana, M. Reza

AU - De Paiva, Cintia S.

AU - Fleiszig, Susanne

AU - Hazlett, Linda D.

AU - Huang, Andrew J.

AU - Jones, Dan B.

AU - Liu, Yong Jun

AU - McDermott, Allison M.

AU - Mircheff, Austin K.

AU - Niederkorn, Jerry Y.

AU - Perez, Victor

AU - Perlman, Eric

AU - Rosenbaum, Jim

AU - Theofilopoulus, Argyrios

AU - Wilhelmu, Kirk

N1 - Funding Information: Supported in part by an unrestricted grant from Allergan, Inc, Irvine, CA.

PY - 2009

Y1 - 2009

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KW - Antigen-presenting cells

KW - Autoimmune reaction

KW - Immunoregulatory systems

KW - Inflammation

KW - Regulatory T cells

KW - Toll-like receptors

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Immunoregulation on the ocular surface: 2nd cullen symposium

Abstract

Keywords

ASJC Scopus subject areas

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