Immunotherapies in Neurologic Disorders

Donna Graves, Steven Vernino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Therapy for autoimmune demyelinating disorders has evolved rapidly over the past 10 years to include traditional immunosuppressants as well as novel biologicals. Antibody-mediated neuromuscular disorders are treated with therapies that acutely modulate pathogenic antibodies or chronically inhibit the humoral immune response. In other inflammatory autoimmune disorders of the peripheral and central nervous system, corticosteroids, often combined with conventional immunosuppression, and immunomodulatory treatments are used. Because autoimmune neurologic disorders are so diverse, evidence from randomized controlled trials is limited for most of the immunotherapies used in neurology. This review provides an overview of the immunotherapies currently used for neurologic disorders.

Original languageEnglish (US)
Pages (from-to)497-523
Number of pages27
JournalMedical Clinics of North America
Volume96
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Nervous System Diseases
Immunotherapy
Autoimmune Diseases of the Nervous System
Antibodies
Peripheral Nervous System
Demyelinating Diseases
Immunosuppressive Agents
Neurology
Humoral Immunity
Immunosuppression
Adrenal Cortex Hormones
Therapeutics
Central Nervous System
Randomized Controlled Trials

Keywords

  • Autoimmune encephalopathy
  • Intravenous immunoglobulin
  • Multiple sclerosis
  • Myasthenia gravis
  • Neuromyelitis optica
  • Paraneoplastic neurologic disorders

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immunotherapies in Neurologic Disorders. / Graves, Donna; Vernino, Steven.

In: Medical Clinics of North America, Vol. 96, No. 3, 05.2012, p. 497-523.

Research output: Contribution to journalArticle

Graves, Donna ; Vernino, Steven. / Immunotherapies in Neurologic Disorders. In: Medical Clinics of North America. 2012 ; Vol. 96, No. 3. pp. 497-523.
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