Immunotoxins

J. Michael Lord; Lynne M. Roberts; Philip E. Thorpe; Ellen S. Vitetta

doi:10.1016/0167-7799(85)90118-0

Immunotoxins

J. Michael Lord, Lynne M. Roberts, Philip E. Thorpe, Ellen S. Vitetta

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Many types of tumour cell express high levels of surface antigens which are largely absent from normal cells. Monoclonal antibodies against these surface antigens can be coupled to potent toxins to form conjugates (immunotoxins) which selectively kill the antigen-bearing cells. This article describes the components of immunotoxins, their modes of action and their clinical applications.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Trends in Biotechnology
Volume	3
Issue number	7
DOIs	https://doi.org/10.1016/0167-7799(85)90118-0
State	Published - Jul 1985

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/0167-7799(85)90118-0

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@article{a6fe1687de4d4593ad07a61a309ff8bd,

title = "Immunotoxins",

abstract = "Many types of tumour cell express high levels of surface antigens which are largely absent from normal cells. Monoclonal antibodies against these surface antigens can be coupled to potent toxins to form conjugates (immunotoxins) which selectively kill the antigen-bearing cells. This article describes the components of immunotoxins, their modes of action and their clinical applications.",

author = "Lord, {J. Michael} and Roberts, {Lynne M.} and Thorpe, {Philip E.} and Vitetta, {Ellen S.}",

year = "1985",

month = jul,

doi = "10.1016/0167-7799(85)90118-0",

language = "English (US)",

volume = "3",

pages = "175--179",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Elsevier Limited",

number = "7",

}

TY - JOUR

T1 - Immunotoxins

AU - Lord, J. Michael

AU - Roberts, Lynne M.

AU - Thorpe, Philip E.

AU - Vitetta, Ellen S.

PY - 1985/7

Y1 - 1985/7

N2 - Many types of tumour cell express high levels of surface antigens which are largely absent from normal cells. Monoclonal antibodies against these surface antigens can be coupled to potent toxins to form conjugates (immunotoxins) which selectively kill the antigen-bearing cells. This article describes the components of immunotoxins, their modes of action and their clinical applications.

AB - Many types of tumour cell express high levels of surface antigens which are largely absent from normal cells. Monoclonal antibodies against these surface antigens can be coupled to potent toxins to form conjugates (immunotoxins) which selectively kill the antigen-bearing cells. This article describes the components of immunotoxins, their modes of action and their clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=0021995914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021995914&partnerID=8YFLogxK

U2 - 10.1016/0167-7799(85)90118-0

DO - 10.1016/0167-7799(85)90118-0

M3 - Review article

AN - SCOPUS:0021995914

SN - 0167-7799

VL - 3

SP - 175

EP - 179

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 7

ER -

Immunotoxins

Abstract

ASJC Scopus subject areas

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