Immunotoxins

J. Michael Lord, Lynne M. Roberts, Philip E. Thorpe, Ellen S. Vitetta

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Many types of tumour cell express high levels of surface antigens which are largely absent from normal cells. Monoclonal antibodies against these surface antigens can be coupled to potent toxins to form conjugates (immunotoxins) which selectively kill the antigen-bearing cells. This article describes the components of immunotoxins, their modes of action and their clinical applications.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalTrends in Biotechnology
Volume3
Issue number7
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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    Lord, J. M., Roberts, L. M., Thorpe, P. E., & Vitetta, E. S. (1985). Immunotoxins. Trends in Biotechnology, 3(7), 175-179. https://doi.org/10.1016/0167-7799(85)90118-0