Immunotoxins

Arthur E. Frankel, Jung Hee Woo, David M. Neville

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

Immunotoxins are protein molecules composed of a cell surface-directed ligand covalently linked to a peptide cytotoxin. This definition excludes a number of important therapeutic compounds with distinct pharmacologic properties which react with intracellular targets. Such molecules would be unlikely to find and react with their intracellular targets due to the permeability barrier of the plasma membrane. Thus, the ligands must bind cell surface receptors or antigens. Ligands which have been used include monoclonal antibodies and antibody fragments, adhesion molecules, growth factors, and cytok-ines.

Original languageEnglish (US)
Title of host publicationPrinciples of Cancer Biotherapy
Subtitle of host publication5th Edition
PublisherSpringer Netherlands
Pages407-449
Number of pages43
ISBN (Print)9789048122776
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Frankel, A. E., Woo, J. H., & Neville, D. M. (2009). Immunotoxins. In Principles of Cancer Biotherapy: 5th Edition (pp. 407-449). Springer Netherlands. https://doi.org/10.1007/978-90-481-2289-9_11