Immunotoxins: A new approach to cancer therapy

Ellen S. Vitetta, Keith A. Krolick, Muneo Miyama-Inaba, William Cushley, Jonathan W. Uhr

Research output: Contribution to journalReview article

208 Scopus citations

Abstract

Conjugates of tumor-reactive antibody and toxins (immunotoxins) have been used to eradicate tumor cells in vitro and in vivo. Such immunotoxins are highly effective in killing murine leukemic cells in infiltrated bone marrow and should be useful in the bone marrow rescue approach for the treatment of cancer. Similar immunotoxins injected parentally can help to induce prolonged remissions in leukemic mice, and antigen-containing immunotoxins can induce immunologic unresponsiveness in vitro in normal murine splenocytes. Thus, long-range goals for the parental use of immunotoxins include the killing of cancer cells in vivo and the modulation of the immune response for therapeutic purposes.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalScience
Volume219
Issue number4585
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • General

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    Vitetta, E. S., Krolick, K. A., Miyama-Inaba, M., Cushley, W., & Uhr, J. W. (1983). Immunotoxins: A new approach to cancer therapy. Science, 219(4585), 644-649. https://doi.org/10.1126/science.6218613