Immunotoxins: A new approach to cancer therapy

Ellen S. Vitetta, Keith A. Krolick, Muneo Miyama-Inaba, William Cushley, Jonathan W. Uhr

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207 Citations (Scopus)

Abstract

Conjugates of tumor-reactive antibody and toxins (immunotoxins) have been used to eradicate tumor cells in vitro and in vivo. Such immunotoxins are highly effective in killing murine leukemic cells in infiltrated bone marrow and should be useful in the bone marrow rescue approach for the treatment of cancer. Similar immunotoxins injected parentally can help to induce prolonged remissions in leukemic mice, and antigen-containing immunotoxins can induce immunologic unresponsiveness in vitro in normal murine splenocytes. Thus, long-range goals for the parental use of immunotoxins include the killing of cancer cells in vivo and the modulation of the immune response for therapeutic purposes.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalScience
Volume219
Issue number4585
StatePublished - 1983

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Immunotoxins
Neoplasms
Bone Marrow
Neoplasm Antibodies
Therapeutics
Antigens

ASJC Scopus subject areas

  • General

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Vitetta, E. S., Krolick, K. A., Miyama-Inaba, M., Cushley, W., & Uhr, J. W. (1983). Immunotoxins: A new approach to cancer therapy. Science, 219(4585), 644-649.

Immunotoxins : A new approach to cancer therapy. / Vitetta, Ellen S.; Krolick, Keith A.; Miyama-Inaba, Muneo; Cushley, William; Uhr, Jonathan W.

In: Science, Vol. 219, No. 4585, 1983, p. 644-649.

Research output: Contribution to journalArticle

Vitetta, ES, Krolick, KA, Miyama-Inaba, M, Cushley, W & Uhr, JW 1983, 'Immunotoxins: A new approach to cancer therapy', Science, vol. 219, no. 4585, pp. 644-649.
Vitetta ES, Krolick KA, Miyama-Inaba M, Cushley W, Uhr JW. Immunotoxins: A new approach to cancer therapy. Science. 1983;219(4585):644-649.
Vitetta, Ellen S. ; Krolick, Keith A. ; Miyama-Inaba, Muneo ; Cushley, William ; Uhr, Jonathan W. / Immunotoxins : A new approach to cancer therapy. In: Science. 1983 ; Vol. 219, No. 4585. pp. 644-649.
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