Impact of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

G. A. Cherednichenko, A. A. Moibenko, I. A. Butovich, S. A. Ogii

Research output: Contribution to journalArticle

Abstract

In this in vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC50=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca2+ transport and of membrane-bound enzymes.

Original languageEnglish (US)
Pages (from-to)895-897
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume120
Issue number3
DOIs
StatePublished - 1995

Keywords

  • Ca transport
  • hydroperoxylinoleic acid
  • Na,K-ATPase
  • sarcolemma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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