Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients

The Q-Cohort Study

Shigeru Tanaka, Toshiharu Ninomiya, Masatomo Taniguchi, Masanori Tokumoto, Kosuke Masutani, Hiroaki Ooboshi, Takanari Kitazono, Kazuhiko Tsuruya

Research output: Contribution to journalArticle

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Abstract

The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR with overall survival was analyzed using a Cox regression model. During a 4-year follow-up period, 545 patients died from any cause and 582 experienced MACE, 392 with coronary heart disease (CHD), 114 with infection-related death, 77 with hemorrhagic stroke, 141 with ischemic stroke, and 107 with cancer death. Every 1 increase in UCR level was significantly associated with an increased risk for all-cause mortality (hazard ratio [HR] 1.07; 95% confidence interval [CI] 1.03-1.12), CHD (HR 1.08; 95% CI 1.02-1.14), and infection-related death (HR 1.11; 95% CI 1.02-1.21). There was no evidence of a significant association between UCR and death from cancer, and incidence of stroke. A high UCR was significantly associated with an increased risk for all-cause mortality, infection-related death and incidence of CHD in hemodialysis patients.

Original languageEnglish (US)
Article number14901
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Blood Urea Nitrogen
Renal Dialysis
Creatinine
Cohort Studies
Morbidity
Mortality
Coronary Disease
Stroke
Confidence Intervals
Infection
Survival
Incidence
Proportional Hazards Models
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Tanaka, S., Ninomiya, T., Taniguchi, M., Tokumoto, M., Masutani, K., Ooboshi, H., ... Tsuruya, K. (2017). Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study. Scientific Reports, 7(1), [14901]. https://doi.org/10.1038/s41598-017-14205-2

Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients : The Q-Cohort Study. / Tanaka, Shigeru; Ninomiya, Toshiharu; Taniguchi, Masatomo; Tokumoto, Masanori; Masutani, Kosuke; Ooboshi, Hiroaki; Kitazono, Takanari; Tsuruya, Kazuhiko.

In: Scientific Reports, Vol. 7, No. 1, 14901, 01.12.2017.

Research output: Contribution to journalArticle

Tanaka, S, Ninomiya, T, Taniguchi, M, Tokumoto, M, Masutani, K, Ooboshi, H, Kitazono, T & Tsuruya, K 2017, 'Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study', Scientific Reports, vol. 7, no. 1, 14901. https://doi.org/10.1038/s41598-017-14205-2
Tanaka, Shigeru ; Ninomiya, Toshiharu ; Taniguchi, Masatomo ; Tokumoto, Masanori ; Masutani, Kosuke ; Ooboshi, Hiroaki ; Kitazono, Takanari ; Tsuruya, Kazuhiko. / Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients : The Q-Cohort Study. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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